GEM (gene)

GTP binding protein overexpressed in skeletal muscle
PDB rendering based on 2cjw.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2cjw​, 2g3y​, 2ht6​
Identifiers
Symbols	GEM ; KIR; MGC26294
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38024
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

GTP binding protein overexpressed in skeletal muscle, also known as GEM, is a human gene.

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Further reading

• Cohen L, Mohr R, Chen YY; et al. (1995). "Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12448–52. PMID 7809057.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maguire J, Santoro T, Jensen P; et al. (1994). "Gem: an induced, immediate early protein belonging to the Ras family". Science. 265 (5169): 241–4. PMID 7912851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Santoro T, Maguire J, McBride OW; et al. (1997). "Chromosomal organization and transcriptional regulation of human GEM and localization of the human and mouse GEM loci encoding an inducible Ras-like protein". Genomics. 30 (3): 558–64. doi:10.1006/geno.1995.1277. PMID 8825643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moyers JS, Bilan PJ, Zhu J, Kahn CR (1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. PMID 9115241.CS1 maint: Multiple names: authors list (link)
• Béguin P, Nagashima K, Gonoi T; et al. (2001). "Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem". Nature. 411 (6838): 701–6. doi:10.1038/35079621. PMID 11395774.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ward Y, Yap SF, Ravichandran V; et al. (2002). "The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway". J. Cell Biol. 157 (2): 291–302. doi:10.1083/jcb.200111026. PMID 11956230.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aresta S, de Tand-Heim MF, Béranger F, de Gunzburg J (2003). "A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases". Biochem. J. 367 (Pt 1): 57–65. doi:10.1042/BJ20020829. PMID 12093360.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kelly K (2006). "The RGK family: a regulatory tail of small GTP-binding proteins". Trends Cell Biol. 15 (12): 640–3. doi:10.1016/j.tcb.2005.10.002. PMID 16242932.
• Opatowsky Y, Sasson Y, Shaked I; et al. (2006). "Structure-function studies of the G-domain from human gem, a novel small G-protein". FEBS Lett. 580 (25): 5959–64. doi:10.1016/j.febslet.2006.09.067. PMID 17052716.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Splingard A, Ménétrey J, Perderiset M; et al. (2007). "Biochemical and structural characterization of the gem GTPase". J. Biol. Chem. 282 (3): 1905–15. doi:10.1074/jbc.M604363200. PMID 17107948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)