MSRA (gene)

Methionine sulfoxide reductase A
Identifiers
Symbols	MSRA ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5812
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MSRA 219281 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Methionine sulfoxide reductase A, also known as MSRA, is a human gene.

This protein is ubiquitous and highly conserved. It carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. Its proposed function is the repair of oxidative damage to proteins to restore biological activity.

Further reading

• Hansel A, Heinemann SH, Hoshi T (2005). "Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation". Biochim. Biophys. Acta. 1703 (2): 239–47. doi:10.1016/j.bbapap.2004.09.010. PMID 15680232.CS1 maint: Multiple names: authors list (link)
• Moskovitz J, Jenkins NA, Gilbert DJ; et al. (1996). "Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3205–8. PMID 8622914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuschel L, Hansel A, Schönherr R; et al. (1999). "Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA)". FEBS Lett. 456 (1): 17–21. PMID 10452521.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hansel A, Kuschel L, Hehl S; et al. (2002). "Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins". FASEB J. 16 (8): 911–3. doi:10.1096/fj.01-0737fje. PMID 12039877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vougier S, Mary J, Friguet B (2003). "Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells". Biochem. J. 373 (Pt 2): 531–7. doi:10.1042/BJ20030443. PMID 12693988.CS1 maint: Multiple names: authors list (link)
• Picot CR, Perichon M, Cintrat JC; et al. (2004). "The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts". FEBS Lett. 558 (1–3): 74–8. doi:10.1016/S0014-5793(03)01530-8. PMID 14759519.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kantorow M, Hawse JR, Cowell TL; et al. (2004). "Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress". Proc. Natl. Acad. Sci. U.S.A. 101 (26): 9654–9. doi:10.1073/pnas.0403532101. PMID 15199188.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• De Luca A, Sacchetta P, Di Ilio C, Favaloro B (2006). "Identification and analysis of the promoter region of the human methionine sulphoxide reductase A gene". Biochem. J. 393 (Pt 1): 321–9. doi:10.1042/BJ20050973. PMID 16162094.CS1 maint: Multiple names: authors list (link)
• Picot CR, Petropoulos I, Perichon M; et al. (2006). "Overexpression of MsrA protects WI-38 SV40 human fibroblasts against H2O2-mediated oxidative stress". Free Radic. Biol. Med. 39 (10): 1332–41. doi:10.1016/j.freeradbiomed.2005.06.017. PMID 16257642.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee JW, Gordiyenko NV, Marchetti M; et al. (2006). "Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina". Exp. Eye Res. 82 (5): 816–27. doi:10.1016/j.exer.2005.10.003. PMID 16364291.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schallreuter KU, Rübsam K, Chavan B; et al. (2006). "Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus". Biochem. Biophys. Res. Commun. 342 (1): 145–52. doi:10.1016/j.bbrc.2006.01.124. PMID 16480945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lei KF, Wang YF, Zhu XQ; et al. (2007). "Identification of MSRA gene on chromosome 8p as a candidate metastasis suppressor for human hepatitis B virus-positive hepatocellular carcinoma". BMC Cancer. 7: 172. doi:10.1186/1471-2407-7-172. PMID 17784942.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)