VAV2

Vav 2 oncogene
File:PBB Protein VAV2 image.jpg PDB rendering based on 2dlz.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2dlz​, 2dm1​
Identifiers
Symbols	VAV2 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2530
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE VAV2 205536 at tn.png
File:PBB GE VAV2 205537 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Vav 2 oncogene, also known as VAV2, is a human gene.

VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.

Further reading

• Romero F, Fischer S (1997). "Structure and function of vav". Cell. Signal. 8 (8): 545–53. PMID 9115846.
• Henske EP, Short MP, Jozwiak S; et al. (1995). "Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1". Ann. Hum. Genet. 59 (Pt 1): 25–37. PMID 7762982.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smit L, van der Horst G, Borst J (1996). "Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors". J. Biol. Chem. 271 (15): 8564–9. PMID 8621483.CS1 maint: Multiple names: authors list (link)
• Tamma SM, Chirmule N, Yagura H; et al. (1997). "CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells". Blood. 90 (4): 1588–93. PMID 9269777.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• De Sepulveda P, Okkenhaug K, Rose JL; et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". EMBO J. 18 (4): 904–15. doi:10.1093/emboj/18.4.904. PMID 10022833.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pandey A, Podtelejnikov AV, Blagoev B; et al. (2000). "Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors". Proc. Natl. Acad. Sci. U.S.A. 97 (1): 179–84. PMID 10618391.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moores SL, Selfors LM, Fredericks J; et al. (2000). "Vav family proteins couple to diverse cell surface receptors". Mol. Cell. Biol. 20 (17): 6364–73. PMID 10938113.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu BP, Burridge K (2000). "Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins". Mol. Cell. Biol. 20 (19): 7160–9. PMID 10982832.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Doody GM, Billadeau DD, Clayton E; et al. (2001). "Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes". EMBO J. 19 (22): 6173–84. doi:10.1093/emboj/19.22.6173. PMID 11080163.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tartare-Deckert S, Monthouel MN, Charvet C; et al. (2001). "Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte". J. Biol. Chem. 276 (24): 20849–57. doi:10.1074/jbc.M010588200. PMID 11262396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Teckchandani AM, Feshchenko EA, Tsygankov AY (2001). "c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases". Oncogene. 20 (14): 1739–55. doi:10.1038/sj.onc.1204246. PMID 11313921.CS1 maint: Multiple names: authors list (link)
• Jevremovic D, Billadeau DD, Schoon RA; et al. (2001). "Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2". J. Immunol. 166 (12): 7219–28. PMID 11390470.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marignani PA, Carpenter CL (2001). "Vav2 is required for cell spreading". J. Cell Biol. 154 (1): 177–86. PMID 11448999.
• Tamás P, Solti Z, Buday L (2001). "Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor". Cell. Signal. 13 (7): 475–81. PMID 11516622.CS1 maint: Multiple names: authors list (link)
• Bourguignon LY, Zhu H, Zhou B; et al. (2002). "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth". J. Biol. Chem. 276 (52): 48679–92. doi:10.1074/jbc.M106759200. PMID 11606575.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Booden MA, Campbell SL, Der CJ (2002). "Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation". Mol. Cell. Biol. 22 (8): 2487–97. PMID 11909943.CS1 maint: Multiple names: authors list (link)
• Tamás P, Solti Z, Bauer P; et al. (2003). "Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac". J. Biol. Chem. 278 (7): 5163–71. doi:10.1074/jbc.M207555200. PMID 12454019.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)