GADD45G
| Growth arrest and DNA-damage-inducible, gamma | |||||||||
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| Identifiers | |||||||||
| Symbols | GADD45G ; CR6; DDIT2; GADD45gamma; GRP17 | ||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 21334 | ||||||||
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| Species | Human | Mouse | |||||||
| Entrez | n/a | n/a | |||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||
| RefSeq (protein) | n/a | n/a | |||||||
| Location (UCSC) | n/a | n/a | |||||||
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Growth arrest and DNA-damage-inducible, gamma, also known as GADD45G, is a human gene.[1]
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta.[1]
See also
References
Further reading
- Beadling C, Johnson KW, Smith KA (1993). "Isolation of interleukin 2-induced immediate-early genes". Proc. Natl. Acad. Sci. U.S.A. 90 (7): 2719–23. PMID 7681987.
- Takekawa M, Saito H (1998). "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK". Cell. 95 (4): 521–30. PMID 9827804.
- Nakayama K, Hara T, Hibi M; et al. (1999). "A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth". J. Biol. Chem. 274 (35): 24766–72. PMID 10455148.
- Zhang W, Bae I, Krishnaraju K; et al. (1999). "CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control". Oncogene. 18 (35): 4899–907. doi:10.1038/sj.onc.1202885. PMID 10490824.
- Suzuki M, Watanabe TK, Fujiwara T; et al. (1999). "Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118". J. Hum. Genet. 44 (5): 300–3. PMID 10496071.
- Fan W, Richter G, Cereseto A; et al. (2000). "Cytokine response gene 6 induces p21 and regulates both cell growth and arrest". Oncogene. 18 (47): 6573–82. doi:10.1038/sj.onc.1203054. PMID 10597261.
- Gong R, Yu L, Zhang H; et al. (2000). "Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping". Cytogenet. Cell Genet. 88 (1–2): 95–6. PMID 10773677.
- Yi YW, Kim D, Jung N; et al. (2000). "Gadd45 family proteins are coactivators of nuclear hormone receptors". Biochem. Biophys. Res. Commun. 272 (1): 193–8. PMID 10872826.
- Yang Q, Manicone A, Coursen JD; et al. (2001). "Identification of a functional domain in a GADD45-mediated G2/M checkpoint". J. Biol. Chem. 275 (47): 36892–8. doi:10.1074/jbc.M005319200. PMID 10973963.
- Azam N, Vairapandi M, Zhang W; et al. (2001). "Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control". J. Biol. Chem. 276 (4): 2766–74. doi:10.1074/jbc.M005626200. PMID 11022036.
- Wan Y, Wang Z, Shao Y; et al. (2001). "UV-induced expression of GADD45 is mediated by an oxidant sensitive pathway in cultured human keratinocytes and in human skin in vivo". Int. J. Mol. Med. 6 (6): 683–8. PMID 11078829.
- Kovalsky O, Lung FD, Roller PP, Fornace AJ (2001). "Oligomerization of human Gadd45a protein". J. Biol. Chem. 276 (42): 39330–9. doi:10.1074/jbc.M105115200. PMID 11498536.
- Zhang X, Sun H, Danila DC; et al. (2002). "Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis". J. Clin. Endocrinol. Metab. 87 (3): 1262–7. PMID 11889197.
- Vairapandi M, Balliet AG, Hoffman B, Liebermann DA (2002). "GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress". J. Cell. Physiol. 192 (3): 327–38. doi:10.1002/jcp.10140. PMID 12124778.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Chung HK, Yi YW, Jung NC; et al. (2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". J. Biol. Chem. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909.
- Sun L, Gong R, Wan B; et al. (2004). "GADD45gamma, down-regulated in 65% hepatocellular carcinoma (HCC) from 23 chinese patients, inhibits cell growth and induces cell cycle G2/M arrest for hepatoma Hep-G2 cell lines". Mol. Biol. Rep. 30 (4): 249–53. PMID 14672412.
- Jiang F, Wang Z (2004). "Gadd45gamma is androgen-responsive and growth-inhibitory in prostate cancer cells". Mol. Cell. Endocrinol. 213 (2): 121–9. doi:10.1016/j.mce.2003.10.050. PMID 15062559.
- Zerbini LF, Wang Y, Czibere A; et al. (2004). "NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival". Proc. Natl. Acad. Sci. U.S.A. 101 (37): 13618–23. doi:10.1073/pnas.0402069101. PMID 15353598.
- Goehler H, Lalowski M, Stelzl U; et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
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