PSIP1
| PC4 and SFRS1 interacting protein 1 | |||||||||||||
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File:PBB Protein PSIP1 image.jpg PDB rendering based on 1z9e. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PSIP1 ; p75; p52; DFS70; LEDGF; MGC74712; PAIP; PSIP2 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 13242 | ||||||||||||
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| RNA expression pattern | |||||||||||||
| File:PBB GE PSIP1 210758 at tn.png | |||||||||||||
| File:PBB GE PSIP1 205961 s at tn.png | |||||||||||||
| File:PBB GE PSIP1 209337 at tn.png | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||||
| RefSeq (protein) | n/a | n/a | |||||||||||
| Location (UCSC) | n/a | n/a | |||||||||||
| PubMed search | n/a | n/a | |||||||||||
PC4 and SFRS1 interacting protein 1, also known as PSIP1, is a human gene.[1] It is thought to impede the replication of HIV.
References
- Van Maele B, Debyser Z (2005). "HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins". AIDS reviews. 7 (1): 26–43. PMID 15875659.
- Van Maele B, Busschots K, Vandekerckhove L; et al. (2006). "Cellular co-factors of HIV-1 integration". Trends Biochem. Sci. 31 (2): 98–105. doi:10.1016/j.tibs.2005.12.002. PMID 16403635.
- Freed EO, Mouland AJ (2006). "The cell biology of HIV-1 and other retroviruses". Retrovirology. 3: 77. doi:10.1186/1742-4690-3-77. PMID 17083721.
- Ge H, Si Y, Roeder RG (1999). "Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation". EMBO J. 17 (22): 6723–9. doi:10.1093/emboj/17.22.6723. PMID 9822615.
- Ge H, Si Y, Wolffe AP (1999). "A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2". Mol. Cell. 2 (6): 751–9. PMID 9885563.
- Singh DP, Ohguro N, Kikuchi T; et al. (2000). "Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts". Biochem. Biophys. Res. Commun. 267 (1): 373–81. doi:10.1006/bbrc.1999.1979. PMID 10623627.
- Singh DP, Kimura A, Chylack LT, Shinohara T (2000). "Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing". Gene. 242 (1–2): 265–73. PMID 10721720.
- Ochs RL, Muro Y, Si Y; et al. (2000). "Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1211–20. PMID 10856157.
- Kubo E, Fatma N, Sharma P; et al. (2002). "Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived growth factor (LEDGF)". J. Mol. Biol. 320 (5): 1053–63. PMID 12126624.
- Wu X, Daniels T, Molinaro C; et al. (2003). "Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders". Cell Death Differ. 9 (9): 915–25. doi:10.1038/sj.cdd.4401063. PMID 12181742.
- Cherepanov P, Maertens G, Proost P; et al. (2003). "HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells". J. Biol. Chem. 278 (1): 372–81. doi:10.1074/jbc.M209278200. PMID 12407101.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Maertens G, Cherepanov P, Pluymers W; et al. (2003). "LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells". J. Biol. Chem. 278 (35): 33528–39. doi:10.1074/jbc.M303594200. PMID 12796494.
- Maertens G, Cherepanov P, Debyser Z; et al. (2004). "Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75". J. Biol. Chem. 279 (32): 33421–9. doi:10.1074/jbc.M404700200. PMID 15163664.
- Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
- Llano M, Vanegas M, Fregoso O; et al. (2004). "LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes". J. Virol. 78 (17): 9524–37. doi:10.1128/JVI.78.17.9524-9537.2004. PMID 15308744.
- Cherepanov P, Devroe E, Silver PA, Engelman A (2005). "Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase". J. Biol. Chem. 279 (47): 48883–92. doi:10.1074/jbc.M406307200. PMID 15371438.
- Llano M, Delgado S, Vanegas M, Poeschla EM (2005). "Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase". J. Biol. Chem. 279 (53): 55570–7. doi:10.1074/jbc.M408508200. PMID 15475359.
- Ogawa Y, Sugiura K, Watanabe A; et al. (2005). "Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain". J. Autoimmun. 23 (3): 221–31. doi:10.1016/j.jaut.2004.07.003. PMID 15501393.
- Okamoto M, Ogawa Y, Watanabe A; et al. (2005). "Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients". J. Autoimmun. 23 (3): 257–66. doi:10.1016/j.jaut.2004.07.004. PMID 15501396.
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