FCN2

Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
PDB rendering based on 2j0g.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2j0g​, 2j0h​, 2j0y​, 2j1g​, 2j2p​, 2j3f​, 2j3g​, 2j3o​, 2j3u​, 2j61​
Identifiers
Symbols	FCN2 ; EBP-37; FCNL; P35; ficolin-2
External IDs	Template:OMIM5 HomoloGene: 3031
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), also known as FCN2, is a human gene.

The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Lu J, Le Y (1999). "Ficolins and the fibrinogen-like domain". Immunobiology. 199 (2): 190–9. PMID 9777405.
• Edgar PF (1996). "Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-beta 1-binding proteins". FEBS Lett. 375 (1–2): 159–61. PMID 7498469.
• Matsushita M, Endo Y, Taira S; et al. (1996). "A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin". J. Biol. Chem. 271 (5): 2448–54. PMID 8576206.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Endo Y, Sato Y, Matsushita M, Fujita T (1997). "Cloning and characterization of the human lectin P35 gene and its related gene". Genomics. 36 (3): 515–21. doi:10.1006/geno.1996.0497. PMID 8884275.CS1 maint: Multiple names: authors list (link)
• Le Y, Tan SM, Lee SH; et al. (1997). "Purification and binding properties of a human ficolin-like protein". J. Immunol. Methods. 204 (1): 43–9. PMID 9202708.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kilpatrick DC, Fujita T, Matsushita M (1999). "P35, an opsonic lectin of the ficolin family, in human blood from neonates, normal adults, and recurrent miscarriage patients". Immunol. Lett. 67 (2): 109–12. PMID 10232391.CS1 maint: Multiple names: authors list (link)
• Taira S, Kodama N, Matsushita M, Fujita T (2001). "Opsonic function and concentration of human serum ficolin/P35". Fukushima journal of medical science. 46 (1–2): 13–23. PMID 11446374.CS1 maint: Multiple names: authors list (link)
• Cseh S, Vera L, Matsushita M; et al. (2003). "Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2". J. Immunol. 169 (10): 5735–43. PMID 12421953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohashi T, Erickson HP (2004). "The disulfide bonding pattern in ficolin multimers". J. Biol. Chem. 279 (8): 6534–9. doi:10.1074/jbc.M310555200. PMID 14660572.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lynch NJ, Roscher S, Hartung T; et al. (2004). "L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement". J. Immunol. 172 (2): 1198–202. PMID 14707097.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krarup A, Thiel S, Hansen A; et al. (2005). "L-ficolin is a pattern recognition molecule specific for acetyl groups". J. Biol. Chem. 279 (46): 47513–9. doi:10.1074/jbc.M407161200. PMID 15331601.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Herpers BL, Immink MM, de Jong BA; et al. (2006). "Coding and non-coding polymorphisms in the lectin pathway activator L-ficolin gene in 188 Dutch blood bank donors". Mol. Immunol. 43 (7): 851–5. doi:10.1016/j.molimm.2005.06.035. PMID 16076493.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanio M, Kondo S, Sugio S, Kohno T (2006). "Overexpression, purification and preliminary crystallographic analysis of human M-ficolin fibrinogen-like domain". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 (Pt 7): 652–5. doi:10.1107/S1744309106019786. PMID 16820685.CS1 maint: Multiple names: authors list (link)
• Chen X, Katoh Y, Nakamura K; et al. (2006). "Single nucleotide polymorphisms of Ficolin 2 gene in Behçet's disease". J. Dermatol. Sci. 43 (3): 201–5. doi:10.1016/j.jdermsci.2006.05.010. PMID 16839748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Garlatti V, Belloy N, Martin L; et al. (2007). "Structural insights into the innate immune recognition specificities of L- and H-ficolins". EMBO J. 26 (2): 623–33. doi:10.1038/sj.emboj.7601500. PMID 17215869.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chapman SJ, Vannberg FO, Khor CC; et al. (2007). "Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease". Mol. Immunol. 44 (12): 3267–70. doi:10.1016/j.molimm.2006.04.013. PMID 17382393.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Munthe-Fog L, Hummelshøj T, Hansen BE; et al. (2007). "The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels". Scand. J. Immunol. 65 (4): 383–92. doi:10.1111/j.1365-3083.2007.01915.x. PMID 17386030.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)