CKS2

CDC28 protein kinase regulatory subunit 2
PDB rendering based on 1cks.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1cks​
Identifiers
Symbols	CKS2 ; CKSHS2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 86883
Gene ontology Molecular function Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

CDC28 protein kinase regulatory subunit 2, also known as CKS2, is a human gene.

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein.

Further reading

• Richardson HE, Stueland CS, Thomas J; et al. (1990). "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe". Genes Dev. 4 (8): 1332–44. PMID 2227411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Parge HE, Arvai AS, Murtari DJ; et al. (1993). "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control". Science. 262 (5132): 387–95. PMID 8211159.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Demetrick DJ, Zhang H, Beach DH (1996). "Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22". Cytogenet. Cell Genet. 73 (3): 250–4. PMID 8697818.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Le XF, Lammayot A, Gold D; et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gorr IH, Boos D, Stemmann O (2005). "Mutual inhibition of separase and Cdk1 by two-step complex formation". Mol. Cell. 19 (1): 135–41. doi:10.1016/j.molcel.2005.05.022. PMID 15989971.CS1 maint: Multiple names: authors list (link)
• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rother K, Dengl M, Lorenz J; et al. (2007). "Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73". FEBS Lett. 581 (6): 1166–72. doi:10.1016/j.febslet.2007.02.028. PMID 17336302.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bertheau P, Turpin E, Rickman DS; et al. (2007). "Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen". PLoS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMID 17388661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)