MTCP1
| Mature T-cell proliferation 1 | |||||||||||||
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File:PBB Protein MTCP1 image.jpg PDB rendering based on 1a1x. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MTCP1 ; C6.1B | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 82921 | ||||||||||||
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| RNA expression pattern | |||||||||||||
| File:PBB GE MTCP1 216862 s at tn.png | |||||||||||||
| File:PBB GE MTCP1 205106 at tn.png | |||||||||||||
| File:PBB GE MTCP1 210212 x at tn.png | |||||||||||||
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| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||||
| Location (UCSC) | n/a | n/a | |||||||||||
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Mature T-cell proliferation 1, also known as MTCP1, is a human gene.[1]
This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. The gene has two ORFs that encode two different proteins. The upstream ORF encodes a 13kDa protein that is a member of the TCL1 family; this protein may be involved in leukemogenesis. The downstream ORF encodes an 8kDa protein that localizes to mitochondria. Alternative splicing results in multiple transcript variants.[1]
References
Further reading
- Kenwrick S, Levinson B, Taylor S; et al. (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): 179–86. PMID 1303175.
- Madani A, Soulier J, Schmid M; et al. (1995). "The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein". Oncogene. 10 (11): 2259–62. PMID 7784073.
- Soulier J, Madani A, Cacheux V; et al. (1994). "The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation". Oncogene. 9 (12): 3565–70. PMID 7970717.
- Thick J, Mak YF, Metcalfe J; et al. (1994). "A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia". Leukemia. 8 (4): 564–73. PMID 8152252.
- Fisch P, Forster A, Sherrington PD; et al. (1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another". Oncogene. 8 (12): 3271–6. PMID 8247530.
- Stern MH, Soulier J, Rosenzwajg M; et al. (1993). "MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations". Oncogene. 8 (9): 2475–83. PMID 8361760.
- Madani A, Choukroun V, Soulier J; et al. (1996). "Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations". Blood. 87 (5): 1923–7. PMID 8634440.
- Gritti C, Choukroun V, Soulier J; et al. (1997). "Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations". Oncogene. 15 (11): 1329–35. doi:10.1038/sj.onc.1201303. PMID 9315101.
- Barthe P, Yang YS, Chiche L; et al. (1998). "Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif". J. Mol. Biol. 274 (5): 801–15. doi:10.1006/jmbi.1997.1438. PMID 9405159.
- Du Bois GC, Song SP, Kulikovskaya I; et al. (1998). "Purification and characterization of recombinant forms of TCL-1 and MTCP-1 proteins". Protein Expr. Purif. 12 (2): 215–25. doi:10.1006/prep.1997.0822. PMID 9518463.
- Fu ZQ, Du Bois GC, Song SP; et al. (1998). "Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3413–8. PMID 9520380.
- Yang YS, Guignard L, Padilla A; et al. (1998). "Solution structure of the recombinant human oncoprotein p13MTCP1". J. Biomol. NMR. 11 (3): 337–54. PMID 9691281.
- Guignard L, Padilla A, Mispelter J; et al. (2000). "Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data". J. Biomol. NMR. 17 (3): 215–30. PMID 10959629.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
- Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
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