ENOX2

Cytosolic ovarian carcinoma antigen 1
Identifiers
Symbols	COVA1 ; APK1; tNOX
External IDs	Template:OMIM5 Template:MGI HomoloGene: 17120
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cytosolic ovarian carcinoma antigen 1, also known as COVA1, is a human gene.

The protein encoded by this gene is a growth-related cell surface protein. It was identifed because it reacts with the monoclonal antibody KI in cells, such as the ovarian carcinoma line OVCAR-3, also expressing the CAKI surface glycoprotein. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The two activities alternate with a period length of about 24 minutes. The encoded protein also displays prion-like properties. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Tarasoutchi F, Grinberg M, de Figueiredo Neto JA; et al. (1991). "[Mitral valve aneurysm associated with mitral insufficiency in absence of aortic insufficiency]". Arq. Bras. Cardiol. 56 (3): 231–4. PMID 1888291.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang K, Pastan I (1994). "Molecular cloning and expression of a cDNA encoding a protein detected by the K1 antibody from an ovarian carcinoma (OVCAR-3) cell line". Int. J. Cancer. 57 (1): 90–7. PMID 8150545.
• Dai S, Morré DJ, Geilen CC; et al. (1997). "Inhibition of plasma membrane NADH oxidase activity and growth of HeLa cells by natural and synthetic retinoids". Mol. Cell. Biochem. 166 (1–2): 101–9. PMID 9046026.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morré DJ, Chueh PJ, Lawler J, Morré DM (1999). "The sulfonylurea-inhibited NADH oxidase activity of HeLa cell plasma membranes has properties of a protein disulfide-thiol oxidoreductase with protein disulfide-thiol interchange activity". J. Bioenerg. Biomembr. 30 (5): 477–87. PMID 9932650.CS1 maint: Multiple names: authors list (link)
• Kishi T, Morré DM, Morré DJ (1999). "The plasma membrane NADH oxidase of HeLa cells has hydroquinone oxidase activity". Biochim. Biophys. Acta. 1412 (1): 66–77. PMID 10354495.CS1 maint: Multiple names: authors list (link)
• Kelker M, Kim C, Chueh PJ; et al. (2001). "Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion". Biochemistry. 40 (25): 7351–4. PMID 11412089.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yantiri F, Morré DJ (2001). "Isolation and characterization of a tumor-associated NADH oxidase (tNOX) from the HeLa cell surface". Arch. Biochem. Biophys. 391 (2): 149–59. doi:10.1006/abbi.2001.2404. PMID 11437345.
• Morré DJ, Sedlak D, Tang X; et al. (2001). "Surface NADH oxidase of HeLa cells lacks intrinsic membrane binding motifs". Arch. Biochem. Biophys. 392 (2): 251–6. doi:10.1006/abbi.2001.2436. PMID 11488599.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chueh PJ, Morré DM, Morré DJ (2002). "A site-directed mutagenesis analysis of tNOX functional domains". Biochim. Biophys. Acta. 1594 (1): 74–83. PMID 11825610.CS1 maint: Multiple names: authors list (link)
• Chueh PJ, Kim C, Cho N; et al. (2002). "Molecular cloning and characterization of a tumor-associated, growth-related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface". Biochemistry. 41 (11): 3732–41. PMID 11888291.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cho N, Chueh PJ, Kim C; et al. (2002). "Monoclonal antibody to a cancer-specific and drug-responsive hydroquinone (NADH) oxidase from the sera of cancer patients". Cancer Immunol. Immunother. 51 (3): 121–9. doi:10.1007/s00262-001-0262-2. PMID 11941450.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morré DJ, Chueh PJ, Pletcher J; et al. (2002). "Biochemical basis for the biological clock". Biochemistry. 41 (40): 11941–5. PMID 12356293.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chueh PJ, Wu LY, Morré DM, Morré DJ (2005). "tNOX is both necessary and sufficient as a cellular target for the anticancer actions of capsaicin and the green tea catechin (-)-epigallocatechin-3-gallate". Biofactors. 20 (4): 235–49. PMID 15706060.CS1 maint: Multiple names: authors list (link)
• Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)