PDK3

Pyruvate dehydrogenase kinase, isozyme 3
File:PBB Protein PDK3 image.jpg PDB rendering based on 1y8n.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1y8n​, 1y8o​, 1y8p​
Identifiers
Symbols	PDK3 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55897
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PDK3 206347 at tn.png
File:PBB GE PDK3 206348 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Pyruvate dehydrogenase kinase, isozyme 3, also known as PDK3, is a human gene. It codes for an isozyme of pyruvate dehydrogenase kinase.

Further reading

• Sugden MC, Holness MJ (2003). "Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia". Curr. Drug Targets Immune Endocr. Metabol. Disord. 2 (2): 151–65. PMID 12476789.
• Sugden MC, Holness MJ (2003). "Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs". Am. J. Physiol. Endocrinol. Metab. 284 (5): E855–62. doi:10.1152/ajpendo.00526.2002. PMID 12676647.
• Gudi R, Bowker-Kinley MM, Kedishvili NY; et al. (1996). "Diversity of the pyruvate dehydrogenase kinase gene family in humans". J. Biol. Chem. 270 (48): 28989–94. PMID 7499431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baker JC, Yan X, Peng T; et al. (2000). "Marked differences between two isoforms of human pyruvate dehydrogenase kinase". J. Biol. Chem. 275 (21): 15773–81. doi:10.1074/jbc.M909488199. PMID 10748134.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kolobova E, Tuganova A, Boulatnikov I, Popov KM (2001). "Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites". Biochem. J. 358 (Pt 1): 69–77. PMID 11485553.CS1 maint: Multiple names: authors list (link)
• Korotchkina LG, Patel MS (2001). "Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase". J. Biol. Chem. 276 (40): 37223–9. doi:10.1074/jbc.M103069200. PMID 11486000.
• Tuganova A, Boulatnikov I, Popov KM (2002). "Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex". Biochem. J. 366 (Pt 1): 129–36. doi:10.1042/BJ20020301. PMID 11978179.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Spriet LL, Tunstall RJ, Watt MJ; et al. (2005). "Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting". J. Appl. Physiol. 96 (6): 2082–7. doi:10.1152/japplphysiol.01318.2003. PMID 14966024.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blackshaw S, Harpavat S, Trimarchi J; et al. (2006). "Genomic analysis of mouse retinal development". PLoS Biol. 2 (9): E247. doi:10.1371/journal.pbio.0020247. PMID 15226823.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato M, Chuang JL, Tso SC; et al. (2005). "Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex". EMBO J. 24 (10): 1763–74. doi:10.1038/sj.emboj.7600663. PMID 15861126.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tso SC, Kato M, Chuang JL, Chuang DT (2006). "Structural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex". J. Biol. Chem. 281 (37): 27197–204. doi:10.1074/jbc.M604339200. PMID 16849321.CS1 maint: Multiple names: authors list (link)
• Devedjiev Y, Steussy CN, Vassylyev DG (2007). "Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications". J. Mol. Biol. 370 (3): 407–16. doi:10.1016/j.jmb.2007.04.083. PMID 17532006.CS1 maint: Multiple names: authors list (link)
• Degenhardt T, Saramäki A, Malinen M; et al. (2007). "Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta". J. Mol. Biol. 372 (2): 341–55. doi:10.1016/j.jmb.2007.06.091. PMID 17669420.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato M, Li J, Chuang JL, Chuang DT (2007). "Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol". Structure. 15 (8): 992–1004. doi:10.1016/j.str.2007.07.001. PMID 17683942.CS1 maint: Multiple names: authors list (link)