IRAK1

Interleukin-1 receptor-associated kinase 1
Identifiers
Symbols	IRAK1 ; IRAK; pelle
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37496
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Interleukin-1 receptor-associated kinase 1, also known as IRAK1, is a human gene.

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Further reading

• Auron PE (1999). "The interleukin 1 receptor: ligand interactions and signal transduction". Cytokine Growth Factor Rev. 9 (3–4): 221–37. PMID 9918122.
• Cao Z, Henzel WJ, Gao X (1996). "IRAK: a kinase associated with the interleukin-1 receptor". Science. 271 (5252): 1128–31. PMID 8599092.CS1 maint: Multiple names: authors list (link)
• Cao Z, Xiong J, Takeuchi M; et al. (1996). "TRAF6 is a signal transducer for interleukin-1". Nature. 383 (6599): 443–6. doi:10.1038/383443a0. PMID 8837778.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.CS1 maint: Multiple names: authors list (link)
• Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. PMID 9371760.CS1 maint: Multiple names: authors list (link)
• Muzio M, Ni J, Feng P, Dixit VM (1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. PMID 9374458.CS1 maint: Multiple names: authors list (link)
• Muzio M, Natoli G, Saccani S; et al. (1998). "The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)". J. Exp. Med. 187 (12): 2097–101. PMID 9625770.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maschera B, Ray K, Burns K, Volpe F (1999). "Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB". Biochem. J. 339 ( Pt 2): 227–31. PMID 10191251.CS1 maint: Multiple names: authors list (link)
• Wesche H, Gao X, Li X; et al. (1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". J. Biol. Chem. 274 (27): 19403–10. PMID 10383454.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang RB, Mark MR, Gurney AL, Godowski PJ (1999). "Signaling events induced by lipopolysaccharide-activated toll-like receptor 2". J. Immunol. 163 (2): 639–43. PMID 10395652.CS1 maint: Multiple names: authors list (link)
• Thomas JA, Allen JL, Tsen M; et al. (1999). "Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase". J. Immunol. 163 (2): 978–84. PMID 10395695.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reichwald K, Thiesen J, Wiehe T; et al. (2000). "Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions". Mamm. Genome. 11 (3): 182–90. PMID 10723722.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burns K, Clatworthy J, Martin L; et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Böl G, Kreuzer OJ, Brigelius-Flohé R (2000). "Translocation of the interleukin-1 receptor-associated kinase-1 (IRAK-1) into the nucleus". FEBS Lett. 477 (1–2): 73–8. PMID 10899313.CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Vig E, Green M, Liu Y; et al. (2001). "SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity". J. Biol. Chem. 276 (11): 7859–66. doi:10.1074/jbc.M010399200. PMID 11096118.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li X, Commane M, Jiang Z, Stark GR (2001). "IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4461–5. doi:10.1073/pnas.071054198. PMID 11287640.CS1 maint: Multiple names: authors list (link)
• Jensen LE, Whitehead AS (2001). "IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability". J. Biol. Chem. 276 (31): 29037–44. doi:10.1074/jbc.M103815200. PMID 11397809.
• Qian Y, Commane M, Ninomiya-Tsuji J; et al. (2001). "IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B.". J. Biol. Chem. 276 (45): 41661–7. doi:10.1074/jbc.M102262200. PMID 11518704.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)