CDY1

Chromodomain protein, Y-linked, 1
PDB rendering based on 2fbm.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2fbm​, 2fw2​
Identifiers
Symbols	CDY1 ; CDY; CDY1A; CDY2; MGC163298; MGC163300; CDY1
External IDs	Template:OMIM5 HomoloGene: 36165
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chromodomain protein, Y-linked, 1, also known as CDY1, is a human gene.

This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined.

Further reading

• Jones DO, Cowell IG, Singh PB (2000). "Mammalian chromodomain proteins: their role in genome organisation and expression". Bioessays. 22 (2): 124–37. doi:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E. PMID 10655032.CS1 maint: Multiple names: authors list (link)
• Lahn BT, Page DC (1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. PMID 9381176.
• Yen PH (1999). "A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males". Genomics. 54 (1): 5–12. doi:10.1006/geno.1998.5526. PMID 9806824.
• Lahn BT, Page DC (1999). "Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome". Nat. Genet. 21 (4): 429–33. doi:10.1038/7771. PMID 10192397.
• Saut N, Terriou P, Navarro A; et al. (2000). "The human Y chromosome genes BPY2, CDY1 and DAZ are not essential for sustained fertility". Mol. Hum. Reprod. 6 (9): 789–93. PMID 10956550.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kleiman SE, Lagziel A, Yogev L; et al. (2001). "Expression of CDY1 may identify complete spermatogenesis". Fertil. Steril. 75 (1): 166–73. PMID 11163833.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ferlin A, Moro E, Rossi A, Foresta C (2001). "CDY1 analysis in infertile patients with DAZ deletions". J. Endocrinol. Invest. 24 (2): RC4–6. PMID 11263480.CS1 maint: Multiple names: authors list (link)
• Lahn BT, Tang ZL, Zhou J; et al. (2002). "Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis". Proc. Natl. Acad. Sci. U.S.A. 99 (13): 8707–12. doi:10.1073/pnas.082248899. PMID 12072557.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kostova E, Röttger S, Schempp W, Gromoll J (2003). "Identification and characterization of the cynomolgus monkey chromodomain gene cynCDY, an orthologue of the human CDY gene family". Mol. Hum. Reprod. 8 (8): 702–9. PMID 12149400.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ; et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dorus S, Gilbert SL, Forster ML; et al. (2003). "The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence". Hum. Mol. Genet. 12 (14): 1643–50. PMID 12837688.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kleiman SE, Yogev L, Hauser R; et al. (2003). "Members of the CDY family have different expression patterns: CDY1 transcripts have the best correlation with complete spermatogenesis". Hum. Genet. 113 (6): 486–92. doi:10.1007/s00439-003-0990-9. PMID 14569460.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)