Lactose intolerance historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]
Overview
Lactose intolerance first discovered by Hippocrate, ancient Greek physician 2500 years ago. In 1906, Pimmer discovered lactase enzyme in the intestine of infant dogs, pigs, and rats. The association between ethnic and lactose intolerance was discovered in 1966 by Bayless and Rosensweig. In1978, breath hydrogen test was used by Levitt, to diagnose lactose intolerance.
Historical Perspective
Discovery
- Lactose intolerance first discovered by Hippocrate, ancient Greek physician 2500 years ago.[1]
- In 1906, Pimmer was the first scientist that discovered lactase enzyme in the intestine of infant dogs, pigs, and rats; also he found that this enzyme decreases in the adult intestine of these animals.[1]
- In 1959, Durand and Holzei et al decribed congenital lactase deficiency[1]
- The association between ethnic and lactose intolerance was discovered in 1966 by Bayless and Rosensweig and in 1968 by Neale.
- In early 1970s, lactase-phlorizin hydrolase (LPH) gene mutations were first implicated in the pathogenesis of lactose intolerance.[2]
Landmark Events in the Development of Treatment Strategies
- In1978, breath hydrogen test was used by Levitt, to diagnose lactose intolerance.[3]
References
- ↑ 1.0 1.1 1.2 Neale G (1973). "The geographical incidence of lactase deficiency". Pathol Microbiol (Basel). 39 (3): 238–47. PMID 4718561.
- ↑ Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Järvelä I (2002). "Identification of a variant associated with adult-type hypolactasia". Nat. Genet. 30 (2): 233–7. doi:10.1038/ng826. PMID 11788828.
- ↑ Rana SV, Malik A (2014). "Hydrogen breath tests in gastrointestinal diseases". Indian J Clin Biochem. 29 (4): 398–405. doi:10.1007/s12291-014-0426-4. PMC 4175689. PMID 25298621.