Gallbladder cancer pathophysiology
Overview
It is thought that gallbladder cancer is the result of chronic irritation of the gallbladder mucosa over a duration of years may predispose to malignant transformation.
Pathophysiology
Chronic inflammation:
- It is understood that gallbladder cancer is the result of chronic irritation or inflmation of the gallbladder
- In most of patients (>75%), the nidus of this chronic inflammation is gallstones.
- Gallbladder cancer affects most commonly females 2-3 times than males[1]
- In carcinogenesis of gallbladder cancer, Chronic inflammation is directly propotional to malignant transformation
- Chronic inflammation leads to deoxyribonucleic acid (DNA) damage, Releasing cytokines and growth factor in response to inflamation predispose to malignant transformation