Anal fissure pathophysiology

Anal fissure Microchapters
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Overview
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Pathophysiology
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Differentiating Anal Fissure from other Diseases
Epidemiology and Demographics
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Natural History, Complications and Prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Overview

The exact pathogenesis of anal fissure is not fully understood. It is thought that anal fissure is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].

OR

[Pathogen name] is usually transmitted via the [transmission route] route to the human host.

anal fissure arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].

OR

The progression to anal fissure usually involves the [molecular pathway].

OR

The pathophysiology of [disease/malignancy] depends on the histological subtype.

Pathophysiology

Anal canal

Pathogenesis

• The exact pathogenesis of anal fissure is not fully understood.
• It is understood that anal fissure is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
• [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
• Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
• [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
• The progression to anal fissure usually involves the [molecular pathway].
• The pathophysiology of anal fissure depends on the histological subtype.

Genetics

• anal fissure is transmitted in [mode of genetic transmission] pattern.
• Genes involved in the pathogenesis of anal fissure include [gene1], [gene2], and [gene3].
• The development of anal fissure is the result of multiple genetic mutations.

Gross Pathology

• On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of anal fissure.

Microscopic Pathology

• On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of anal fissure.

References

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