Anal fissure pathophysiology

	Anal fissure Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Anal Fissure from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Abdominal X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Anal fissure pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Anal fissure pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Anal fissure pathophysiology
CDC on Anal fissure pathophysiology
Anal fissure pathophysiology in the news
Blogs on Anal fissure pathophysiology
Directions to Hospitals Treating Anal fissure
Risk calculators and risk factors for Anal fissure pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Overview

The exact pathogenesis of anal fissure is not fully understood. It is thought that anal fissure is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].

OR

[Pathogen name] is usually transmitted via the [transmission route] route to the human host.

anal fissure arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].

OR

The progression to anal fissure usually involves the [molecular pathway].

OR

The pathophysiology of [disease/malignancy] depends on the histological subtype.

Pathophysiology

Pathogenesis

Although constipation or anal trauma was supposed to instigate the fissure,the exact pathogenesis of anal fissure is not fully understood.^[2]
It is understood that anal fissure is the result of either anal trauma (by hard stools/diarrhea), perfusion defects with ischemia caused due to increased anal pressures and decreased blood flow or increased anal sphincter tone.

Associated Conditions

Gross Pathology

On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of anal fissure.

Microscopic Pathology

On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of anal fissure.

References

↑ Source=http://www.surgwiki.com/wiki/File:Ch31-fig1.jpg
↑ Zaghiyan KN, Fleshner P (2011). "Anal fissure". Clin Colon Rectal Surg. 24 (1): 22–30. doi:10.1055/s-0031-1272820. PMC 3140330. PMID 22379402.

Template:WikiDoc Sources

[1] Source=http://www.surgwiki.com/wiki/File:Ch31-fig1.jpg

[pmid22379402-2] Zaghiyan KN, Fleshner P (2011). "Anal fissure". Clin Colon Rectal Surg. 24 (1): 22–30. doi:10.1055/s-0031-1272820. PMC 3140330. PMID 22379402.

[1]

[2]