Gastroparesis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]

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Overview

Natural History

Complications

Primary complications of gastroparesis include:

Fluctuations in blood glucose due to unpredictable digestion times (in diabetic patients)
General malnutrition due to the symptoms of the disease (which frequently include vomiting and reduced appetite) as well as the dietary changes necessary to manage it
Severe fatigue and weight loss due to calorie deficit
Intestinal obstruction due to the formation of bezoars (solid masses of undigested food)
Bacterial infection due to overgrowth in undigested food
Dehydration
Electrolyte imbalances

Prognosis

Many treatments seem to provide only temporary benefit. The estimated 5-year survival for gastroparesis based on Gastroparesis study in Olmsted County, MN, as of January 1, 2007 was 67% with worse prognosis for diabetic gastroparesis.^[1]

References

↑ Jung HK, Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Szarka LA; et al. (2009). "The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006". Gastroenterology. 136 (4): 1225–33. doi:10.1053/j.gastro.2008.12.047. PMC 2705939. PMID 19249393.

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[pmid19249393-1] Jung HK, Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Szarka LA; et al. (2009). "The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006". Gastroenterology. 136 (4): 1225–33. doi:10.1053/j.gastro.2008.12.047. PMC 2705939. PMID 19249393.

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