Jaundice natural history, complications, and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

The type and the severity of complications depends on the underlying cause leading to jaundice. Certain individuals may not suffer any long-term complications and recovers fully, while for others the appearance of jaundice may be the first indication of a life-threatening situation.

Natural History

• The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
• The symptoms of (disease name) typically develop ___ years after exposure to ___.
• If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

Complications

Common complications of jaundice include:

• Electrolyte abnormalities
• Anemia
• Bleeding
• Infection/sepsis
• Chronic hepatitis
• Cancer
• Liver failure
• Kidney failure
• Hepatic encephalopathy (brain dysfunction)
• Death

Prognosis

• Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
• Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
• The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
• [Subtype of disease/malignancy] is associated with the most favorable prognosis.
• The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
• The prognosis for individuals with jaundice varies with the underlying cause of the condition. There are certain conditions that has the most favorable prognosis leading to full recovery. However, more serious causes of jaundice like can sometimes be fatal despite medical or surgical intervention. The development and severity of complications will also determine an individual's prognosis, as will a patient's underlying health and comorbidities (presence of other diseases).

References

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