Barrett's esophagus causes
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Barrett's Esophagus Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amresh Kumar MD [2]
Overview
Barrett's Oesophagus is commonly caused by Gastroesophageal reflux disease.
Causes
Gastroesophageal reflux disease (GERD)
There are several anatomo-physiologic abnormalities that may contribute to GERD [1][2][3][4][5]
- Hypersecretion of gastric acid.
- Decreased concentration of epidermal growth factor in salivary secretions.
- Diminished esophageal pain sensitivity.
- Poor contraction of the esophagus.
- Decreased muscle tone of the lower esophageal sphincter.
References
- ↑ Spechler SJ. Barrett's esophagus. Semin Gastrointest Dis 1996; 7:51.
- ↑ Spechler SJ (1996). "Barrett's esophagus". Semin Gastrointest Dis. 7 (2): 51–60. PMID 8705259.
- ↑ Lavy UI, Funcke AB, van Hell G, Timmerman H (1973). "Pharmacological properties of ((3alpha-tropanyl)oxy)-5H-benzo(4,5)cycloheptal(1,2-b)-pyridine hydrogen maleate (BS 7723)". Arzneimittelforschung. 23 (6): 854–8. PMID 4146903.
- ↑ von Schrenck T (2000). "[Diagnosis of gastroesophageal reflux and Barrett esophagus]". Zentralbl Chir. 125 (5): 414–23. PMID 10929625.
- ↑ Minacapelli CD, Bajpai M, Geng X, Cheng CL, Chouthai AA, Souza R; et al. (2017). "Barrett's metaplasia develops from cellular reprograming of esophageal squamous epithelium due to gastroesophageal reflux". Am J Physiol Gastrointest Liver Physiol. 312 (6): G615–G622. doi:10.1152/ajpgi.00268.2016. PMID 28336546.