Takayasu's arteritis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farnaz Khalighinejad, MD [2]
Overview
History
Takayasu's arteritis can be divided into two phases:[1]
- Pre-pulseless phase
- Present with non-specific constitutional symptoms of vasculitis, which may include any of the following
- Subsequent pulseless phase
- With progression of the disease and involvement of the branches of aorta, specific symptoms secondary to narrowing/occlusion of the branches of aorta become evident.
- Subclavian artery:
- claudication in the upper extremities, subclavian steal syndrome
- Carotid and vertebral arteries:
- Headache
- Vertigo
- Syncope
- Convulsions
- Dementia
- Coronary arteries:
- Chest pain
- Angina which may progress to myocardial infarction
- Ascending aorta:
- Aortic regurgiatation
- Subclavian artery:
- With progression of the disease and involvement of the branches of aorta, specific symptoms secondary to narrowing/occlusion of the branches of aorta become evident.
Common Symptoms
Common symptoms of Takayasu's arteritis include:
- Headache
- Malaise
- Arthralgias
- Bruit, with the most common location being the carotid artery (80%)
- Blood pressure difference of extremities (45%-69%)
- Claudication (38-81%)
- Hypertension (28-53%; 58% with renal artery stenosis in one series
- Visual disturbance
Less Common Symptoms
Less common symptoms of Takayasu's arteritis include:
- Fever
- Weight loss
- Carotodynia or vessel tenderness
- Raynaud syndrome
- Stroke (5-9%)
- Transient ischemic attacks (3-7%)
- Seizures
- Erythema nodosum (6-19%)
- Ulcerated subacute nodular lesions (<2.5%)
- Pyoderma gangrenosum
- Angina
- Gastrointestinal symptoms