Restless legs syndrome laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
laboratory findings are usually normal for patients with restless leg syndrome.
Laboratory Findings
- As restless leg syndrome may be secondary to iron deficiency or kidney diseases or thyroid diseases, all patients should be screened for iron deficiency, kidney diseases and thyroid diseases.
- Iron studies usually done for detecting iron deficiency anemia in patients with restless leg syndrome usually are:[1]
- Serum iron- Decreased in iron deficiency
- Transferrin- Elevated in iron deficiency
- Total iron binding capacity (TIBC)- Elevated in iron deficiency
- Transferrin saturation- derived by dividing the serum iron by the TIBC. Decreased in iron deficiency
- Ferritin- Indicator of body iron stores and is low in iron deficiency. However, ferritin also acts as an acute phase reactant and can be unreliable in inflammatory illness
- kidney function tests which usually done for detecting kidney diseases in patients with restless leg syndrome usually are:[2]
- Blood urea nitrogen (BUN)
- Creatinine
thyroid function tests which usually done for detecting kidney diseases in patients with restless leg syndrome usually are:[3]
References
- ↑ Johnson-Wimbley TD, Graham DY (2011). "Diagnosis and management of iron deficiency anemia in the 21st century". Therap Adv Gastroenterol. 4 (3): 177–84. doi:10.1177/1756283X11398736. PMC 3105608. PMID 21694802.
- ↑ Gade K, Blaschke S, Rodenbeck A, Becker A, Anderson-Schmidt H, Cohrs S (2013). "Uremic restless legs syndrome (RLS) and sleep quality in patients with end-stage renal disease on hemodialysis: potential role of homocysteine and parathyroid hormone". Kidney Blood Press Res. 37 (4–5): 458–63. doi:10.1159/000355727. PMID 24247595.
- ↑ Pereira JC, Pradella-Hallinan M, Lins Pessoa Hd (2010). "Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis". Clinics (Sao Paulo). 65 (5): 548–54. doi:10.1590/S1807-59322010000500013. PMC 2882550. PMID 20535374.