Adult-onset Still's disease medical therapy
|
Adult-onset Still's disease |
|
Differentiating Adult-onset Still’s Disease from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Template:Adult-onset Still's disease On the Web |
|
American Roentgen Ray Society Images of Template:Adult-onset Still's disease |
|
Template:Adult-onset Still's disease in the news |
|
Risk calculators and risk factors for Template:Adult-onset Still's disease |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief:
Overview
Medical Therapy
Medical therapy in adult-onset Still's disease (AOSD) is guided by disease activity and severity. The following agents may be used in the management of AOSD:[1]
- 1.1 Adults
- Preferred regimen (1): Prednisone PO 0.8-1 mg/kg/day
- 1.2 Adults (Steroid dependence)
- Preferred regimen (1): Methotrexate 7.5-20 mg/week
- Alternative regimen (1): Combination of prednisolone 20 mg/day plus oral methotrexate 5 mg/week plus cyclosporin A 5.5 mg/kg/day
- 1.3 Adults (Refractory AOSD)
- 1.3.1 Chronic arthritis
- Preferred regimen (1): Infliximab IV initial 3 mg/kg at 0, 2, and 6 weeks; then 3 to 6 mg/kg/dose every 8 weeks
- Preferred regimen (2): Tocilizumab IV 8 mg/kg
- Alternative regimen (1): Leflunomide <20 kg: 100 mg as a single dose followed by 10 mg every other day; 20 kg to 40 kg: 100 mg once daily for 2 days followed by 10 mg once daily; >40 kg: 100 mg once daily for 3 days followed by 20 mg once daily and Azathioprine initial1 mg/kg/day (50 to 100 mg) given once daily or divided twice daily; after 6 to 8 weeks, may increase by 0.5 mg/kg every 4 weeks until response or up to 2.5 mg/kg/day; an adequate trial should be a minimum of 12 weeks
- 1.3.2 Systemic flares
- Preferred regimen (1): Anakinra SC initial 1 to 2 mg/kg once daily; maximum initial dose: 100 mg; if no response after 1 to 2 weeks, may titrate up to 4 mg/kg once daily (maximum: 200 mg/day)
- Alternative regimen (1): Canakinumab SC children ≥2 years and ≥7.5 kg and Adolescents: 4 mg/kg every 4 weeks (maximum: 300 mg per dose)
- Alternative regimen (2): Rilonacept
- 1.3.1 Chronic arthritis
- 1.4 Adults (Complicated AOSD)
- Preferred regimen (1): Methylprednisone IV
- Preferred regimen (2): Immunoglobulin IV (IVIG) 2 g/kg body weight administered in 2–5 days.
- Preferred regimen (3): Cyclophosphamide PO 1 to 5 mg/kg/day (initial and maintenance dosing)
- Preferred regimen (4): Plasma exchange therapy
References
- ↑ Gerfaud-Valentin, Mathieu; Jamilloux, Yvan; Iwaz, Jean; Sève, Pascal (2014). "Adult-onset Still's disease". Autoimmunity Reviews. 13 (7): 708–722. doi:10.1016/j.autrev.2014.01.058. ISSN 1568-9972.