Anti-β2 glycoprotein I antibody

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Mehrian Jafarizade, M.D [2]

Anti-β2 glycoprotein I antibodies along with anti-cardiolipin antibodies and lupus anticoagulant are involved in thrombosis and sclerosis in the antiphospholipid syndrome and autoimmune form of deep vein thrombosis. These antibodies interfere with factor X of coagulation cascade factors. The HLA-DR4-DQ3, DR4-DQ8, and HLA-DR7 are found to be involved in the pathogenesis of these antibodies.[1][2][3][4][5]

References

  1. ↑ Kouttab NM, Fowler AK, Strickland JE, Hellman A (November 1976). "Suprresion of in vitro lymphocyte stimulation in mice by uterine and placental extracts". J. Immunol. 117 (5 Pt 1): 1644–50. PMID 137261.
  2. ↑ Galli M, Bevers EM, Comfurius P, Barbui T, Zwaal RF (March 1993). "Effect of antiphospholipid antibodies on procoagulant activity of activated platelets and platelet-derived microvesicles". Br. J. Haematol. 83 (3): 466–72. PMID 8485053.
  3. ↑ Tsutsumi A, Matsuura E, Ichikawa K, Fujisaku A, Mukai M, Kobayashi S, Koike T (September 1996). "Antibodies to beta 2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus". Arthritis Rheum. 39 (9): 1466–74. PMID 8814057.
  4. ↑ Shi W, Chong BH, Hogg PJ, Chesterman CN (August 1993). "Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of the factor Xa generating activity of platelets". Thromb. Haemost. 70 (2): 342–5. PMID 8236146.
  5. ↑ Klitz W, Maiers M, Spellman S, Baxter-Lowe LA, Schmeckpeper B, Williams TM, Fernandez-Viña M (October 2003). "New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): 296–307. PMID 12974796.
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