Acute promyelocytic leukemia future or investigational therapies
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Acute promyelocytic leukemia Microchapters |
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Differentiating Acute promyelocytic leukemia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Future or investigational therapies
- Bromodomain inhibitors: Studies have shown that the bromodomain inhibitor JQ1 may have efficacy in acute promyelocytic leukemia. This is based on the idea that bromodomain and extraterminal (BET) proteins normally function to maintain leukemia, so inhibition of these proteins can have anti-leukemic effect.[1] Bromodomain proteins such as Brd4 play a major role in epigenetics, and the use of small molecule inhibitors like JQ1 may enhance the anti-cancer effect.
References
- ↑ Decker TM, Kluge M, Krebs S, Shah N, Blum H, Friedel CC; et al. (2017). "Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1". Sci Rep. 7 (1): 1684. doi:10.1038/s41598-017-01943-6. PMC 5431861. PMID 28490802.