Wilms' tumor risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

The risk factors of wilms' tumor include family history, congenital anomalies, and associated syndromes.

Risk factors

• Familial Wilms tumor
• Congenital anomaly
  • Hemihyperplasia
  • Urinary tract anomalies, including cryptorchidism and hypospadias
  • Aniridia

• WT1-related syndromes include the following:
  • WAGR syndrome
  • Denys-Drash syndrome and Frasier syndrome
• WT2-related syndromes include the following:
  • Beckwith-Wiedemann syndrome
• Other syndromes include the following:
  • Perlman syndrome.
  • Simpson-Golabi-Behemel syndrome
  • Sotos syndrome
  • 9q22.3 microdeletion syndrome
  • Bloom syndrome
  • Li-Fraumeni syndrome
  • Alagille syndrome