Wilms' tumor risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
The risk factors of wilms tumor include family history, congenital anomalies, and associated syndromes.
Risk factors
- Common risk factors in the development of wilms tumor include:
- Familial Wilms tumor [1]
- Congenital anomaly
- Hemihyperplasia
- Urinary tract anomalies, including cryptorchidism and hypospadias
- Aniridia
- Less common risk factors in the development of wilms tumor include:
- WT1-related syndromes include the following:[2]
- WAGR syndrome
- Denys-Drash syndrome and Frasier syndrome
- WT2-related syndromes include the following:
- Other syndromes include the following:
- Perlman syndrome[4]
- Simpson-Golabi-Behemel syndrome[5]
- Sotos syndrome[6]
- 9q22.3 microdeletion syndrome
- Bloom syndrome[7]
- Li-Fraumeni syndrome[8]
- Alagille syndrome[9]
- WT1-related syndromes include the following:[2]
References
- ↑ National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq
- ↑ National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq
- ↑ Crider-Miller SJ, Reid LH, Higgins MJ, Nowak NJ, Shows TB, Futreal PA, Weissman BE (December 1997). "Novel transcribed sequences within the BWS/WT2 region in 11p15.5: tissue-specific expression correlates with cancer type". Genomics. 46 (3): 355–63. doi:10.1006/geno.1997.5061. PMID 9441738.
- ↑ Morris MR, Astuti D, Maher ER (May 2013). "Perlman syndrome: overgrowth, Wilms tumor predisposition and DIS3L2". Am J Med Genet C Semin Med Genet. 163C (2): 106–13. doi:10.1002/ajmg.c.31358. PMID 23613427.
- ↑ Alton KB, Patrick JE, Shaw C, McGuire JL (1975). "Comparative biotransformation of triflubazam in rats, dogs, and monkeys". Drug Metab. Dispos. 3 (6): 445–52. PMID 1219.
- ↑ Heller BR, Walsh FJ (January 1976). "Changing nursing students' attitudes toward the aged: an experimental study". J Nurs Educ. 15 (1): 9–17. PMID 1479.
- ↑ Berger C, Frappaz D, Leroux D, Blez F, Vercherat M, Bouffet E, Jalbert P, Brunat-Mentigny M (August 1996). "[Wilms tumor and Bloom syndrome]". Arch Pediatr (in French). 3 (8): 802–5. PMID 8998536.
- ↑ Hartley AL, Birch JM, Tricker K, Wallace SA, Kelsey AM, Harris M, Jones PH (June 1993). "Wilms' tumor in the Li-Fraumeni cancer family syndrome". Cancer Genet. Cytogenet. 67 (2): 133–5. PMID 8392435.
- ↑ Bourdeaut F, Guiochon-Mantel A, Fabre M, Martelli H, Patte C, Porta G, Bernard O, Delattre O, Jacquemin E (April 2008). "Alagille syndrome and nephroblastoma: Unusual coincidence of two rare disorders". Pediatr Blood Cancer. 50 (4): 908–11. doi:10.1002/pbc.21255. PMID 17584876.