Wilms' tumor diagnostic study of choice
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Diagnostic Study of Choice
Study of choice
- Histology of the biopsy sample taken during surgery is the gold standard for the diagnosis of wilms tumor.[1][2]
Diagnostic results
The following result of histology is confirmatory of wilms tumor:[3]
- Triphasic histology comprising -
- Epithelial cells
- Blastemal cells
- Stromal cells
- Anaplastic changes
- Most of the tumors of the kidney have a favorable histology(90%).
- If anaplastic changes(3-7%) are found then the outcome is poor.[4]
Sequence of Diagnostic Studies
The surgical examination and biopsy must be performed when:
- If a case of wilms tumor is suspected in North America, then nephrectomy is done immediately.
- Contralateral kidney is also explored to check for disease and lymph node biopsies done.
- Transcutaneous biopsy samples are almost never taken to prevent:
- Tumor spill - If this occurs then whole abdomen radiotherapy has to be done.
References
- ↑ Tentzeris M, Fritz G (May 1973). "[Suction and irrigation drainage in the therapy of acute and chronic osteomyelitis]". Zentralbl Chir (in German). 98 (21): 771–4. PMID 4728859.
- ↑ Stefanowicz J, Sierota D, Balcerska A, Stoba C (2004). "[Wilms' tumour of unfavorable histology--results of treatment with the SIOP 93-01 protocol at the Gdańsk centre. Preliminary report]". Med Wieku Rozwoj (in Polish). 8 (2 Pt 1): 197–200. PMID 15738594.
- ↑ Hansz J, Prazmowska-Owczarek B, Nowicka G (1979). "[Granulocyte adherence in advanced Hodgkin's disease and its dependence on antiproliferative drugs used]". Acta Haematol Pol (in Polish). 10 (1): 7–12. PMID 373364.
- ↑ Stefanowicz J, Sierota D, Balcerska A, Stoba C (2004). "[Wilms' tumour of unfavorable histology--results of treatment with the SIOP 93-01 protocol at the Gdańsk centre. Preliminary report]". Med Wieku Rozwoj (in Polish). 8 (2 Pt 1): 197–200. PMID 15738594.