Diabetic nephropathy causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]
Overview
Causes
- The exact cause of diabetic nephropathy is unknown.
- However, it is thought that hyperfiltration through the renal glomeruli may be responsible for the manifestations of the disease.[1]
- The hyperglycemia in uncontrolled diabetics may increase the expression of transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF), leading to glomerular hypercellularity.
- The occurrence of diabetic nephropathy may be attributed to a genetic factor as it is more common in certain ethnicities. Moreover, certain polymorphism in the angiotensin-converting enzyme has been associated with the development of diabetic nephropathy.[2]
- A recent study has shown an association between folic acid deficiency and the development of diabetic nephropathy.Chiarelli F, Gaspari S, Marcovecchio ML (August 2009). "Role of growth factors in diabetic kidney disease". Horm. Metab. Res. 41 (8): 585–93. doi:10.1055/s-0029-1220752. PMID 19452424.
References
- ↑ Ziyadeh FN (January 2004). "Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator". J. Am. Soc. Nephrol. 15 Suppl 1: S55–7. PMID 14684674.
- ↑ Rask-Madsen C, King GL (January 2010). "Kidney complications: factors that protect the diabetic vasculature". Nat. Med. 16 (1): 40–1. doi:10.1038/nm0110-40. PMID 20057426.