Post-streptococcal glomerulonephritis medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
The mainstay of treatment is pharmacotherapy, however dietary therapy is useful for controlling edema and hypertension. Dietary therapy includes low salt, protein intake, and water restriction. If the streptococcal infection is still present, it should be treated with antibiotics. To control severe hypertension, labetalol
Medical therapy
The mainstay of treatment is pharmacotherapy, however dietary therapy is useful for controlling edema and hypertension
Dietary therapy
- Low salt intake
- Low protein intake
- Water restrictions
Pharmacotherapy
- If the streptococcal infection is still present, it should be treated with antibiotics[1]
- To control severe hypertension, following drugs can be used:
- Preferred regimen: Labetalol 0.5-2 mg/kg/h IV
- If refractory to labetalol then, Preferred regimen: Diazoxide or Nitroprusside 0.5-2 mcg/kg/min IV
- For mild to moderate hypertension:
- Preferred regimen: Furosemide 1-3 mg/kg PO q24h
- For treatment of rapidly progressive crescentic Acute post-streptococcal glomerulonephritis, following regimen is used:[2]
- Preferred regimen: Methylprednisolone
References
- ↑ Zoch-Zwierz W, Wasilewska A, Biernacka A, Tomaszewska B, Winiecka W, Wierciński R, Porowski T (2001). "[The course of post-streptococcal glomerulonephritis depending on methods of treatment for the preceding respiratory tract infection]". Wiad. Lek. (in Polish). 54 (1–2): 56–63. PMID 11344703.
- ↑ Zaffanello M, Cataldi L, Franchini M, Fanos V (April 2010). "Evidence-based treatment limitations prevent any therapeutic recommendation for acute poststreptococcal glomerulonephritis in children". Med. Sci. Monit. 16 (4): RA79–84. PMID 20357732.