Nephrotic syndrome historical perspective
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Overview
Cornelus Roelans of Belgium described in 1484 a child with nephrotic syndrome and “whole body swelling.” One of the first accurate descriptions of nephrotic syndrome in children was made by Theodore Zwinger of Basel in 1722 (5). He also noted decreased urine output and attributed this to “obstruction and compression of the tubules of the kidney,” It was finally in 1827 that Richard Bright (1789–1858) was able to put together the triad of generalized edema, proteinuria, and kidney disease, as presenting features of this disease (11) In 1905, the term “nephrosis” was coined by Müller to describe all “non-inflammatory” diseases of the kidney as a substitute for parenchymatous nephritis, contrasting it with exudative and inflammatory disease, which would retain the name nephritis [1]
References
- ↑ Pal A, Kaskel F (2016). "History of Nephrotic Syndrome and Evolution of its Treatment". Front Pediatr. 4: 56. doi:10.3389/fped.2016.00056. PMC 4885377. PMID 27303658.