Hemolytic-uremic syndrome historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Historical Perspective

• Described by Moschowitz in 1925 - disease with hyaline thrombi in many organs
• Pentad from 1964 case series of 271 published cases:

• Thrombocytopenia
• Microangiopathic hemolytic anemia
• Neurologic symptoms and signs
• Renal function abnormalities
• Fever

• When first described, >90% fatal

HUS first described in 1955 in 5 children with ARF who died with renal cortical necrosis.