Membranous glomerulonephritis laboratory findings

Membranous glomerulonephritis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Ahsan Hussain, M.D.[2]

Overview

• The major laboratory workup includes blood workup, auto-immune workup and urine workup

Laboratory Findings

• The laboratory workup of membranous glomerulonephritis includes blood, urine and anti-bodies workup
  • Comprehensive chemistry panel including serum albumin
  • Complete blood count
  • Urinalysis with examination of the sediment
  • 24-hour urine collection for protein quantification and creatinine clearance
  • ANA and, if positive, anti-double-stranded DNA (antidsDNA), anti-Sm, anti-Ro/SSA, and anti-La/SSB antibodies to rule out autoimmune disease (SLE)
  • Tests for hepatitis B and C viruses and the human immunodeficiency virus (HIV)
  • Serum C3 and C4 complement levels
  • Serum free light chains (SFLCs) and serum protein electrophoresis (SPEP) with immunofixation
  • Phospholipase-A2 -receptor antibody]] (Anti-PLA2R antibody) by enzyme-linked immunosorbent assay (ELISA)