Diabetic nephropathy causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]
Overview
The exact cause of diabetic nephropathy is unknown. However, it is thought that hyperfiltration through the renal glomeruli may be responsible for the manifestations of the disease.
Causes
- The exact cause of diabetic nephropathy is unknown.
- However, it is thought that hyperfiltration through the renal glomeruli may be responsible for the manifestations of the disease.[1]
- The hyperglycemia in uncontrolled diabetics may increase the expression of transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF), leading to glomerular hypercellularity.
- The occurrence of diabetic nephropathy may be attributed to a genetic factor as it is more common in certain ethnicities.
- Certain polymorphism in the angiotensin-converting enzyme has been associated with the development of diabetic nephropathy.[2]
- A recent study has shown an association between folic acid deficiency and the development of diabetic nephropathy.[3]
References
- ↑ Ziyadeh FN (January 2004). "Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator". J. Am. Soc. Nephrol. 15 Suppl 1: S55–7. PMID 14684674.
- ↑ Rask-Madsen C, King GL (January 2010). "Kidney complications: factors that protect the diabetic vasculature". Nat. Med. 16 (1): 40–1. doi:10.1038/nm0110-40. PMID 20057426.
- ↑ Chiarelli F, Gaspari S, Marcovecchio ML (August 2009). "Role of growth factors in diabetic kidney disease". Horm. Metab. Res. 41 (8): 585–93. doi:10.1055/s-0029-1220752. PMID 19452424.