Borderline personality disorder

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Jesus Rosario Hernandez, M.D. [2], Irfan Dotani

Synonyms and keywords: BPD; emotionally unstable personality disorder; unstable self-image; unstable relationships

Overview

Borderline Personality Disorder (BPD) is defined as a personality disorder primarily characterized by emotional dysregulation, extreme "black and white" thinking,"splitting", and chaotic relationships. The general profile of the disorder also typically includes a pervasive instability in mood, interpersonal relationships, self-image, identity, and behavior. Moreover, there may be a disturbance in the individual's sense of self. In extreme cases, this disturbance in the sense of self may lead to periods of dissociation.[1] The disturbances suffered by those with borderline personality disorder have a wide-ranging and pervasive negative impact on many or all of the psychosocial facets of life, including the ability to hold down a job, maintain relationships at home, and interacting in social settings. Comorbidity is common; borderline personality disorder frequently occurs with substance use disorders and mood disorders. Attempted suicide and completed suicide are possible outcomes without proper care and effective therapy. The reference of "BPD" throughout this article refers to borderline personality disorder and not bipolar disorder.

Historical Perspective

  • In the 1930s, there was a debate as to whether BPD should be renamed. The term "borderline" started among clinical use and originated from the idea (now out of favor) of some patients being on the "borderline" between neurosis and psychosis. As a deeper understanding of BPD began to emerge, the disorder could be classified and treated more efficiently once the disorder could be differentiated from neurotic behavior and psychotic behavior.
  • In 1980, BPD only became an official Axis II (personality) diagnosis with the publication of DSM-III.[2]
  • Individuals who are labeled with "Borderline Personality Disorder" feel it is unhelpful and stigmatizing, as well as simply inaccurate, to support a name change.[3] Criticisms have also come from a feminist perspective.[4] It has also been claimed that, in some circles, "borderline" is used as a "garbage can" diagnosis for individuals who are hard to diagnose. This may be interpreted as meaning "nearly psychotic" despite a lack of empirical support for this conceptualization. It may also be used as a generic label for difficult clients or as an excuse for therapy going badly.[5]

Classification

Terminology

  • Alternative suggestions for names include:
  • According to TARA, (Treatment and Research Advancement Association for Personality Disorders) this terminology has "the most likely chance of being adopted by the American Psychiatric Association."[6]
  • An emotional regulation disorder is a term favored by Dr. Marsha Linehan, pioneer of one of the most popular types of BPD therapy.
  • Impulse disorder and Interpersonal regulatory disorder are other valid alternatives, according to Dr. John Gunderson of McLean Hospital in the United States.
  • Dyslimbia has been suggested by Dr. Leland Heller.[7]
  • Mercurial disorder has been proposed by McLean Hospital's Dr. Mary Zanarini.[8]
  • Significantly, the above proposals, if adopted, will likely result in the recognition of BPD as a trauma- and/or mood-related disorder, and should move BPD from Axis II to Axis I in the next DSM (DSM-V, due in 2012).

Pathophysiology

Differential Diagnosis

Epidemiology and Demographics

Prevalence

  • The prevalence of borderline personality disorder is 1600 to 5900 per 100,000 (1.6% to 5.9%) of the overall population.[11]"NIMH » Personality Disorders".</ref>
  • The prevalence of any personality disorder was 9.1%, with borderline personality disorder being 1.4%.
  • Researchers commonly believe that BPD results from a combination of a traumatic childhood, a vulnerable temperament, and stressful maturational events during adolescence or adulthood.[12]
  • Otto Kernberg formulated the theory of Borderline Personality based on a premise of failure to develop in childhood. There are, according to Kernberg, three developmental tasks an individual must accomplish:
    • When one fails to accomplish a certain developmental task, this often corresponds with an increased risk of developing certain psychopathologies.
    • Failing the first developmental task,psychic clarification of self and other, may result in an increased risk to develop varieties of psychosis.
    • Not accomplishing the second task, overcoming splitting, may result in an increased risk to develop a borderline personality. [13]

Causes of Borderline Personality Disorder

Etiology Description
Childhood abuse, Trauma, or Negelct
  • Numerous studies have shown a strong correlation between childhood abuse and the development of BPD.[14][15][16][17]
  • Majority of individuals with BPD report having had a history of abuse, neglect, or separation as young children.[18]
  • Patients with BPD have been found to be significantly more likely to report having been verbally, emotionally, physically, and sexually abused by caretakers of either gender. Patients were also much more likely to report having caretakers (of both genders) deny the validity of their thoughts and feelings. They were also reported to have failed to been provided needed protection.
  • Individuals with ignored child physical care during adolescence are more likely to have borderline personality disorder.
  • Parents (of both sexes) were typically reported to have withdrawn from the child emotionally and to have treated the child inconsistently. Additionally, women with BPD who reported a previous history of neglect by a female caretaker and abuse by a male caretaker were consequently at significantly higher risk for being sexually abused by a non-caretaker (not a parent).[19]
  • It has been suggested that children who experience chronic early maltreatment and Reactive Attachment Disorder go on to develop a variety of personality disorders, including Borderline Personality Disorder.[20]Many of these children are violent and aggressive.[21][22] As adults, these individuals are at risk of developing a variety of psychological problems such as borderline personality disorder.[23][24]
    • According to Joel Paris,"Some researchers, like Judith Herman, believe that BPD is a name given to a particular manifestation of post-traumatic stress disorder (PTSD): In Trauma and Recovery, she theorizes that when PTSD takes a form that emphasizes heavily on its elements of identity and relationship disturbance, the disorder is named BPD; when the somatic (body) elements are emphasized, the disorder is named hysteria; when the dissociative/deformation of consciousness elements are the focus, the disorder is named DID/MPD" (dissociative identity disorder or multiple personality disorder).[25]
Genetics
  • An overview of existing literature suggests that traits related to BPD are influenced by genes. Personality is generally quite heritable; therefore, BPD is likely to have a large genetical factor in that sense. However, studies have had methodological problems for the connection between genetical factors and BPD.[26]
  • A major twin study found that if one identical twin met criteria for BPD, the other also met criteria in approximately a third (35%) of cases.[27]
  • Twins, siblings, and other family studies indicate a partially heritable basis for impulsive aggression, but studies of serotonin-related genes to date have suggested only modest contributions to behavior.[28]
Neurofunction
  • Neurotransmitters implicated in BPD include serotonin, norepinephrine, acetylcholine (related to various emotions and moods), GABA (the brain's major inhibitory neurotransmitter which can stabilize mood change), and glutamate (an excitatory neurotransmitter).
  • Enhanced amygdala activation in BPD has been identified as reflecting the intense and slowly subsiding emotions commonly observed in BPD in response to low-level stressors.
    • The activation of both the amygdala and prefrontal cortical areas can reflect attempts to control intensive emotions during the recall of unresolved life events.[29]
  • Impulsivity or aggression, as sometimes seen in BPD, has been linked to alterations in serotonin function and specific brain regions in the cingulate and the medial and orbital prefrontal cortex.[30]
Other Developmental Factors
  • A few studies suggest that BPD may not necessarily be a trauma-spectrum disorder and that it is biologically distinct from the post-traumatic stress disorder that could be a precursor. The personality symptom clusters seem to be related to specific abuses, but they may be related to more persistent aspects of interpersonal and family environments in childhood.[31]
  • There is evidence for the central role of the family in the development of BPD, including interactions that are negative and critical rather than supportive and empathic, with parental and family behaviors transacting with the child's own behaviors and emotional vulnerabilities.[32]
  • A few findings suggest that BPD may lie on a bipolar spectrum, with a number of points of phenomenological and biological overlap between the affective lability criterion of borderline personality disorder and the extremely rapid cycling bipolar disorders.[33][34]
  • Moreover, a few findings suggest that the DSM-IV BPD diagnosis mixes up two sets of unrelated items: An effective instability dimension related to Bipolar-II and an impulsivity dimension not related to Bipolar-II.[35]

Natural History, Complications and Prognosis

Natural History

  • Studies suggest that individuals with BPD tend to experience frequent, strong and long-lasting states of aversive tension, often triggered by perceived rejection, being alone, or perceived failure.[36]
  • Individuals with BPD may show lability (changeability) between anger and anxiety or between depression and anxiety and temperamental sensitivity to emotive stimuli.[37][38]
  • The negative emotional states particularly associated with BPD have been grouped into four categories:[39]
    • Extreme feelings in general.
    • Feelings of destructiveness or self-destructiveness.
    • Feelings of fragmentation or lack of identity
    • Feelings of victimization
  • Individuals with BPD can be very sensitive to the way others treat them, reacting strongly to perceived criticism or hurtfulness.
  • Their feelings about others often shift from positive to negative, generally after a disappointment or perceived threat of losing someone.
  • Self-image can also change rapidly from extremely positive to extremely negative.
  • Impulsive behaviors are common, including alcohol or drug abuse, unsafe sex, gambling, and recklessness in general.[40]
    • Attachment studies suggest individuals with BPD while being high in intimacy- or novelty-seeking can be hyper-alert to signs of rejection or not being valued and tend towards insecure, ambivalent, preoccupied or fearful attitudes towards relationships.[41][42]
    • They tend to view the world generally as dangerous and malevolent, and themselves as powerless, vulnerable, unacceptable and unsure in self-identity.[41]
  • Individuals with BPD are often described, including by some mental health professionals (and in the DSM-IV), as deliberately manipulative or difficult, but analyses and findings generally trace behaviors to inner pain and turmoil, powerlessness and defensive reactions, or limited coping and communication skills.[43][44][45]
  • There has been limited research on family members' understanding of borderline personality disorder and the extent of burden or negative emotion experienced or expressed by family members.[46] Parents of individuals with BPD have been reported to show co-existing extremes of over-involvement and under-involvement.[47]
  • BPD has been linked to somewhat increased levels of chronic stress and conflict in romantic relationships, decreased satisfaction of romantic partners, abuse, and unwanted pregnancy; these links may largely be general to personality disorder and subsyndromal problems,[48] but such issues are commonly raised in support groups and published literature for partners of individuals with BPD.
  • Suicidal or self-harming behavior is one of the core diagnostic criteria in DSM IV-TR. The management of and recovery from this can be complex and challenging.[49] The suicide rate is approximately 8%-10%.[50]
  • The most recognized form of self-injury is auto-mutilation (cutting the self), usually of the arms, but often other areas such as the legs, chest, belly, and face. Self-injury attempts are highly common among patients and may or may not be carried out with suicidal intent.[51][52]
  • BPD is often characterized by multiple low lethality suicide attempts triggered by seemingly minor incidents, and less commonly by high lethality attempts that are attributed to impulsiveness or comorbid major depression, with interpersonal stressors appearing to be particularly common triggers.[53]
    • Ongoing family interactions and associated vulnerabilities can lead to self-destructive behavior.[47]
    • Stressful life events related to sexual abuse have been found to be a particular trigger for suicide attempts by adolescents with a BPD diagnosis.[54]
  • Co-morbid (co-occurring) conditions in BPD are common. When comparing individuals diagnosed with BPD to those diagnosed with other kinds of personality disorders, the former showed a higher rate of also meeting criteria for:[55]
  • Substance abuse is a common problem in BPD, whether due to impulsivity or as a coping mechanism. 50%-70% of psychiatric inpatients with BPD have been found to meet criteria for a substance use disorder.[56]

Prognosis

  • Poor prognostic factors include:[11]
    • Female gender
    • Adolescence and early adulthood
    • Identity problems
    • Relatives with the same disease

Diagnosis

  • A diagnosis is based on self-reported experiences of patients, as well as markers for the disorder observed by a psychiatrist, psychologist, or another qualified diagnostician through clinical assessment. This profile may be supported and/or corroborated by long-term patterns of behavior as reported by family members, friends, or co-workers. The list of criteria that must be met for diagnosis is outlined in the DSM-IV-TR.[1]
  • An initial assessment generally includes a comprehensive personal and family history. It may also include a physical examination by a physician. Although there are no physiological tests that confirm borderline personality disorder, medical tests may be employed to exclude any co-occurring medical conditions that may present with psychiatric symptoms. These include:

Diagnosis Criteria

DSM-V Diagnostic Criteria for Borderline Personality Disorder[11]

“

A pervasive pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity, beginning by early adulthood and present in a variety of contexts, as indicated by five (or more) of the following:

  1. Frantic efforts to avoid real or imagined abandonment. Note: Do not include suicidal or self-mutilating behavior covered in Criterion 5.
  2. A pattern of unstable and intense interpersonal relationships characterized by alternating between extremes of idealization and devaluation.
  3. Identity disturbance: markedly and persistently unstable self-image or sense of self.
  4. Impulsivity in at least two areas that are potentially self-damaging (e.g., spending, sex, substance abuse, reckless driving, binge eating). Note: Do not include suicidal or self-mutilating behavior covered in Criterion 5.
  5. Recurrent suicidal behavior, gestures, threats, or self-mutilating behavior.
  6. Affective instability due to a marked reactivity of mood (e.g., intense episodic dysphoria, irritability, or anxiety usually lasting a few hours (rarely more than a few days).
  7. Chronic feelings of emptiness.
  8. Inappropriate behavior, intense or uncontrollable anger (e.g., frequent displays of temper, constant anger, recurrent physical fights).
  9. Transient, stress-related paranoid ideation or severe dissociative symptoms.
 ”

Mnemonic

  • A commonly used mnemonic to remember some features of borderline personality disorder is PRAISE:
    • P - Paranoid ideas
    • R - Relationship instability
    • A - Angry outbursts, affective instability, abandonment fears
    • I - Impulsive behavior or identity disturbance
    • S - Suicidal behavior
    • E - Emptiness

Emotionally Unstable Personality Disorder

  • The World Health Organization's (WHO) ICD-10 has a comparable diagnosis called Emotionally Unstable Personality Disorder - Borderline type (F60.31). This requires, in addition to the general criteria for personality disorder:
    • Disturbances among and uncertainty about self-image, aims, and internal preferences (including sexual).
    • Liability to become involved in intense and unstable relationships, often leading to an emotional crisis.
    • Excessive efforts to avoid abandonment; recurrent threats or acts of self-harm; and chronic feelings of emptiness.

Treatment

  • 1 Therapies
    • 1.1 Psychotherapy
      • Simple supportive therapy alone may enhance self-esteem and mobilize the existing strengths of individuals with BPD.[58] Specific psychotherapies may involve sessions over several months or, as is particularly common for personality disorders, several years.
      • Psychotherapy can often be conducted either with individuals or with groups. Group therapy can aid the learning and practice of interpersonal skills and self-awareness by individuals with BPD[59] although drop-out rates may be problematic.[60]
    • 1.2 Dialectical Behavioral Therapy
      • Dialectical behavior therapy is derived from cognitive-behavioral techniques (and can be seen as a form of CBT) but emphasizes an exchange and negotiation between therapist and client, between the rational and the emotional, and between acceptance and change (hence dialectic). Treatment targets are agreed upon, with self-harm issues taking priority.
      • The learning of new skills is a core component - including mindfulness, interpersonal effectiveness (e.g. assertiveness and social skills), coping adaptively with distress and crises; and identifying and regulating emotional reactions.
      • DBT can be based on a biosocial theory of personality functioning in which BPD is seen as a biological disorder of emotional regulation in a social environment experienced as invalidating by the borderline patient.[61]
      • Dialectical behavioral therapy has been found to significantly reduce self-injury and suicidal behavior in individuals with BPD, beyond the effect of usual or expert treatment, and to be better accepted by clients.[62][63] Although, whether it has additional efficacy in the overall treatment of BPD appears less clear.[64] Training nurses in the use of DBT has been found to replace a therapeutic pessimism with a more optimistic understanding and outlook.[65]
    • 1.3 Schema Therapy
      • Schema Therapy (also called Schema-Focused Therapy) is an integrative approach based on cognitive-behavioral or skills-based techniques along with object relations and gestalt approaches. It directly targets deeper aspects of emotion, personality and schemas (fundamental ways of categorizing and reacting to the world). The treatment also focuses on the relationship with the therapist (including a process of "limited re-parenting"), daily life outside of therapy, and traumatic childhood experiences.
      • It was developed by Jeffrey Young and became established in the 1990s. Limited recent research suggests that it is significantly more effective than Transference-Focused Psychotherapy, with half of the individuals with borderline personality disorder assessed as having achieved full recovery after 4 years, with two-thirds showing clinically significant improvement.[66][67] Another very small trial has also suggested efficacy.[68]
    • 1.4 Cognitive Behavioral Therapy
      • Cognitive Behavioral Therapy (CBT) is the most widely used and established psychological treatment for mental disorders, but has appeared less successful in BPD, due partly to difficulties in developing a therapeutic relationship and treatment adherence. Approaches such as DBT and Schema-focused therapy developed partly as an attempt to expand and add to traditional CBT, which uses a limited number of sessions to target specific maladaptive patterns of thought, perception, and behavior. A recent study did find a number of sustained benefits of CBT, in addition to treatment as usual, after an average of 16 sessions over one year.[69]
      • Eye Movement Desensitization and Reprocessing (EMDR) is a treatment for PTSD, a condition closely associated to BPD in many cases. It is similar to CBT and seen by some as a type of CBT, but also includes unique techniques intended to facilitate full emotional processing and coming to terms with traumatic memories.
    • 1.5 Marital or Family Therapy
      • Marital Therapy can be helpful in stabilizing the marital relationship and in reducing marital conflict and stress that can worsen BPD symptoms. Family Therapy or Family Psychoeducation can help educate family members regarding BPD, improve family communication and problem-solving, and provide support to family members in dealing with their loved one's illness.
      • Two patterns of family involvement can help clinicians plan family interventions: overinvolvement and neglect. Borderline patients who are from over-involved families are often actively struggling with a dependency issue by denial or by anger towards their parents.
      • Interest in the use of psychoeducation and skills training approaches for families with borderline members is growing.[59]
    • 1.6 Psychoanalysis
      • Traditional psychoanalysis has become less commonly used than in the past, both in general and in regard to BPD. This intervention has been linked to an exacerbation of BPD symptoms[70] although there is also evidence of the effectiveness of certain techniques in the context of partial hospitalization.[71]
    • 1.7 Transference Focused Psychotherapy
      • Transference-Focused Psychotherapy (TFP) is a form of psychoanalytic therapy dating to the 1960s, rooted in the conceptions of Otto Kernberg on BPD and its underlying structure (borderline personality organization). Unlike in the case of traditional psychoanalysis, the therapist plays a very active role in TFP. In the session, the therapist works on the relationship between the patient and the therapist. The therapist will try to explore and clarify aspects of this relationship so the underlying object relations dyads become clear.
      • Some limited research on TFP suggests it may reduce some symptoms of BPD by affecting certain underlying processes,[72] and that TFP in comparison to Dialectical Behavior Therapy and supportive therapy results in increased reflective functioning (the ability to realistically think about how others think) and a more secure attachment style.[73] Furthermore, TFP has been shown to be as effective as DBT in the improvement of suicidal behavior, and has been more effective than DBT in alleviating anger and in reducing verbal or direct assaultive behavior.[74] Limited research suggests that TFP appears to be less effective than schema-focused therapy while being more effective than no treatment.[66]
    • 1.8 Cognitive Analytic Therapy
      • Cognitive Analytic Therapy (CAT) combines cognitive and psychoanalytic approaches and has been adapted for use by individuals with BPD with mixed results.[75]
  • 2 Medication
    • 2.1 Antidepressants
    • 2.2 Antipsychotics
      • The newer atypical antipsychotics are claimed to have an improved adverse effect profile than the typical antipsychotics. Antipsychotics are also sometimes used to treat distortions in thinking or false perceptions.[77] Use of antipsychotics has varied, from intermittent, for a brief psychotic or dissociative episode, to more general, particularly atypical antipsychotics, for both those diagnosed with bipolar disorder (BiP), as well as those diagnosed with a borderline personality disorder (BPD).
      • Long-term use of antipsychotics is particularly controversial. There are numerous adverse effects with the older medications, notably Tardive dyskinesia (TDK).[78] Atypical antipsychotics are also known for often causing considerable weight gain, with associated health complications.[79]
      • Dosage: One meta-analysis of 14 prior studies has suggested that several atypical antipsychotics, including olanzapine, clozapine, quetiapine and risperidone, may help BPD patients with psychotic-like, impulsive or suicidal symptoms.[80]
  • 3 Mental Health Services and Recovery
    • 3.1 Combining Pharmacotherapy and Psychotherapy
      • In practice, psychotherapy and medication may often be combined but there is limited data on clinical practice.[81] Efficacy studies often assess the effectiveness of interventions when added to 'treatment as usual' (TAU), which may involve general psychiatric services, supportive counseling, medication, and psychotherapy.
      • One small study, which excluded individuals with a comorbid Axis 1 disorder, has indicated that outpatients undergoing Dialectical Behavioral Therapy and taking the antipsychotic Olanzapine show significantly more improvement on some measures related to BPD, compared to those undergoing DBT and taking a placebo pill, although they also experienced weight gain and raised cholesterol.
      • Another small study found that patients who had undergone DBT and then took fluoxetine (Prozac) showed no significant improvements, whereas those who underwent DBT and then took a placebo pill did show significant improvements.[82]
    • 3.2 Difficulties in Therapy
      • There can be unique challenges in the treatment of BPD, eg. hospital care.[83] In psychotherapy, a client may be unusually sensitive to rejection and abandonment and may react negatively (e.g., by harming themselves or withdrawing from treatment) if they sense this. In addition, clinicians may emotionally distance themselves from individuals with BPD for self-protection or due to the stigma associated with the diagnosis, leading to a self-fulfilling prophecy and a cycle of stigmatization to which both patient and therapist may contribute to.[84]
      • Some psychotherapies, for example, DBT, were developed partially to overcome problems with interpersonal sensitivity and maintaining a therapeutic relationship. Adherence to medication regimes is also a problem, due in part to adverse effects, with drop-out rates of between 50% and 88% in medication trials.[85] Comorbid disorders, particularly substance use disorders, can complicate attempts to achieve remission.[86]
    • 3.3 Other Strategies
      • Psychotherapies and medications form a part of the overall context of mental health services and psychosocial needs related to BPD. The evidence base is limited for both. Some individuals may forego them or not benefit (enough) from them. It has been argued that diagnostic categorization can have limited utility in directing therapeutic work in this area and that, in some cases, it is only with reference to past and current relationships that "borderline" behavior can be understood as partly adaptive and how people can best be helped.[87]
      • Numerous other strategies may be used, including alternative medicine techniques (see List of branches of alternative medicine), exercise and physical fitness including team sports, occupational therapy techniques including creative arts, having structure and routine, employment - helping feelings of competence (e.g. self-efficacy), having a social role and being valued by others, boosting self-esteem.[88]
      • Group-based psychological services encourage clients to socialize and participate in both solitary and group activities. These may be in day centers. Therapeutic communities are an example of this, particularly in Europe, although their usage has declined many have specialized in the treatment of severe personality disorder.[89]
      • Psychiatric rehabilitation services aimed at helping people with mental health problems to reduce psychosocial disability, engage in meaningful activities and avoid stigma and social exclusion of people who suffer from BPD. There are also many mutual-support or co-counseling groups run by and for individuals with BPD. A goal may be full recovery rather than reliance on services.
      • Data indicates that substantial percentages of people diagnosed with BPD can achieve remission even within a year or two.[2] A longitudinal study found that six years after being diagnosed with BPD, 56% showed good psychosocial function compared to the 26% at baseline. Although vocational achievement was more limited even compared to those with other personality disorders, those whose symptoms had remitted were significantly more likely to have a good relationship with a spouse/partner, at least one parent, good work/school performance, a sustained work/school history, good global functioning, and good psychosocial functioning.[90]

References

  1. ↑ 1.0 1.1 (2004). Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR (Text Revision). Washington, DC: American Psychiatric Association. ISBN 0890420246. DSM-IV & DSM-IV-TR Borderline Personality Disorder criteria. BehaveNet.com. Retrieved on 2007-09-21.
  2. ↑ 2.0 2.1 Oldham, J. (July 2004). "Borderline Personality Disorder: An Overview" Psychiatric Times XXI (8). Retrieved on 2007-09-21.
  3. ↑ Bogod, E. "Borderline Personality Disorder Label Creates Stigma". mental-health-matters.com. Retrieved on 2007-09-21.
  4. ↑ Shaw and Proctor (2005). "Women at the Margins: A Critique of the Diagnosis of Borderline Personality Disorder" (PDF). Feminism Psychology (15): 483-90. Retrieved on 2007-09-21.
  5. ↑ Grohol, J. Psy.D. (June 22 2007). "Symptoms of Borderline Personality Disorder". PsychCentral.com. Retrieved on 2007-09-21.
  6. ↑ Porr, Valerie MA (November 2001). How Advocacy is Bringing Borderline Personality Disorder Into the Light. tara4bpd.org Axis II. Retrieved on 2007-09-21.
  7. ↑ Heller, L. MD. "A Possible New Name For Borderline Personality Disorder". Biological Unhappiness. Retrieved on 2007-09-21.
  8. ↑ Hunter, Aina (2006-01-24). "Personality, Interrupted". The Village Voice. Retrieved on 2007-09-21.
  9. ↑ Quadrio, C. (December 2005). "Axis One/Axis Two: A disordered borderline" (PDF). Psychology, Psychiatry, and Mental Health Monographs: The Journal of the NSW Institute of Psychiatry (2): 141-156. Retrieved on 2007-09-21.
  10. ↑ Herpertz SC, Bertsch K (2015). "A New Perspective on the Pathophysiology of Borderline Personality Disorder: A Model of the Role of Oxytocin". Am J Psychiatry. 172 (9): 840–51. doi:10.1176/appi.ajp.2015.15020216. PMID 26324303.
  11. ↑ 11.0 11.1 11.2 11.3 Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association. 2013. ISBN 0890425558.
  12. ↑ Zanarini, M.C.; F.R. Frankenburg (1997). "Pathways to the development of borderline personality disorder". Journal of Personality Disorder. 11 (1): 93-104. Retrieved on 2007-09-21.
  13. ↑ Kernberg, O. (2000). Borderline Conditions and Pathological Narcissism. New York: Aronson. ISBN 0876687621.
  14. ↑ Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association (2013) 12.
  15. ↑ Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association (2013) 13.
  16. ↑ Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association (2013) 14.
  17. ↑ "Axis One/Axis Two: A disordered borderline" (PDF). Psychology, Psychiatry, and Mental Health Monographs: The Journal of the NSW Institute of Psychiatry (2): 141-156. Retrieved on 2007-09-21 6.
  18. ↑ 15
  19. ↑ Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association. 2013.16.
  20. ↑ Stiglmayr, C.E.; T. Grathwol, M.M. Leneham, et al. (May 2005). "Aversive tension in patients with borderline personality disorder: a computer-based controlled field study." Acta Psychiatr Scand111 (5): 372-9. Retrieved on 2007-09-21 17.
  21. ↑ Koenigsberg H.W.; P.D. Harvey, V. Mitropoulou, et al. (May 2002). "Characterizing affective instability in borderline personality disorder". Am J Psychiatry 159 (5): 784-8. Retrieved on 2007-09-21. 18
  22. ↑ Meyer, B.; M. Ajchenbrenner, D.P. Bowles (December 2005). "Sensory sensitivity, attachment experiences, and rejection responses among adults with borderline and avoidant features". J Personal Disord 19 (6): 641-58. Retrieved on 2007-09-21. 19
  23. ↑ Zanarini, M.C.; F.R. Frankenburg, C.J. DeLuca, et al. (1998). "The pain of being borderline: dysphoric states specific to borderline personality disorder". Harvard Review of Psychiatry6 (4): 201-7. Retrieved on 2007-09-21. 20
  24. ↑ Stiglmayr, C.E.; T. Grathwol, M.M. Leneham, et al. (May 2005). "Aversive tension in patients with borderline personality disorder: a computer-based controlled field study." Acta Psychiatr Scand111 (5): 372-9. Retrieved on 2007-09-21 17.
  25. ↑ American Psychiatric Association (2001). "Psychiatric Services". Psychiatr Serv (52): 1569-70. Retrieved on 2007-09-21.21
  26. ↑ Hoffman, P.D.; E. Buteau, J.M. Hooley, et al. (2003). "Family members' knowledge about borderline personality disorder: correspondence with their levels of depression, burden, distress, and expressed emotion". Family Process 42 (4): 469-78. Retrieved on 2007-09-21.27
  27. ↑ Allen, D.M.; R.G. Farmer (January – February 1996). "Family relationships of adults with borderline personality disorder". Compr Psychiatry 37 (1): 43-51. Retrieved on 2007-09-21. 28
  28. ↑ 22
  29. ↑ Daley, S.E.; D. Burge, C. Hammen (August 2000). "Borderline personality disorder symptoms as predictors of 4-year romantic relationship dysfunction in young women: addressing issues of specificity". J Abnorm Psychol 109 (3): 451-60. Retrieved on 2007-09-21.29
  30. ↑ 22
  31. ↑ 22
  32. ↑ Levy, K.N.; K.B. Meehan, M. Weber, et al. (March – April 2005). "Attachment and borderline personality disorder: implications for psychotherapy". Psychopathology 38 (2): 64-74. Retrieved on 2007-09-21. 23
  33. ↑ Allen, D.M.; R.G. Farmer (January – February 1996). "Family relationships of adults with BPD". Compr Psychiatry 37 (1): 43-51. Retrieved on 2007-09-21. 24
  34. ↑ 25
  35. ↑ Linehan, M. (1993). Cognitive-behavioral treatment of borderline personality disorder. New York: Guilford. 26
  36. ↑ Stiglmayr, C.E.; T. Grathwol, M.M. Leneham, et al. (May 2005). "Aversive tension in patients with borderline personality disorder: a computer-based controlled field study." Acta Psychiatr Scand 111 (5): 372-9. Retrieved on 2007-09-21.
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  40. ↑ American Psychiatric Association (2001). "Psychiatric Services". Psychiatr Serv (52): 1569-70. Retrieved on 2007-09-21.
  41. ↑ 41.0 41.1
  42. ↑ Levy, K.N.; K.B. Meehan, M. Weber, et al. (March – April 2005). "Attachment and borderline personality disorder: implications for psychotherapy". Psychopathology 38 (2): 64-74. Retrieved on 2007-09-21.
  43. ↑ Potter, N. (April 2006). "What is manipulative behavior, anyway?" J Personal Disord. 20 (2): 139-56; discussion 181-5. Retrieved on 2007-09-21.
  44. ↑ McKay, D.; C.A. Gavigan, S. Kulchycky (2004). "Social skills and sex-role functioning in borderline personality disorder: relationship to self-mutilating behavior". Cogn Behav Ther 33 (1): 27-35. Retrieved on 2007-09-21.
  45. ↑ Linehan, M. (1993). Cognitive-behavioral treatment of borderline personality disorder. New York: Guilford. ISBN 0898621836.
  46. ↑ Hoffman, P.D.; E. Buteau, J.M. Hooley, et al. (2003). "Family members' knowledge about borderline personality disorder: correspondence with their levels of depression, burden, distress, and expressed emotion". Family Process 42 (4): 469-78. Retrieved on 2007-09-21.
  47. ↑ 47.0 47.1 Allen, D.M.; R.G. Farmer (January – February 1996). "Family relationships of adults with borderline personality disorder". Compr Psychiatry 37 (1): 43-51. Retrieved on 2007-09-21.
  48. ↑ Daley, S.E.; D. Burge, C. Hammen (August 2000). "Borderline personality disorder symptoms as predictors of 4-year romantic relationship dysfunction in young women: addressing issues of specificity". J Abnorm Psychol 109 (3): 451-60. Retrieved on 2007-09-21.
  49. ↑ Hawton, K.; E. Townsend, E. Arensman, et al. (1999). "Cochrane Collaboration Psychosocial and pharmacological treatments for deliberate self-harm". Cochrane Database of Systematic Reviews (4). Art. No.: CD001764. DOI: 10.1002/14651858.CD001764. Retrieved on 2007-09-21.
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  53. ↑ Brodsky, B.S.; S.A. Groves, M.A. Oquendo, et al. (June 2006). "Interpersonal precipitants and suicide attempts in borderline personality disorder". Suicide Life Threat Behav 36 (3): 313-22. Retrieved on 2007-09-21.
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See also

Template:DSM personality disorders


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