Thrombotic thrombocytopenic purpura historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Saeedeh Kowsarnia M.D.[2]
Overview
Historical Perspective
- In 1924, Eli Moschcowitz first describe TTP with a pentad of presentation.[1]
- In 1960, plasma infusion was introduced as part of the treatment of a 8-year old patient with chronic anemia and thrombocytopenia by Schulman and colleagues [2].
- In 1978, Upshaw first described the hereditary aspect of the disease which lacked and enzyme in the blood and responded to plasma transfusion .
- Moschcowitz ascribed the disease (incorrectly) to a toxic cause. Moschcowitz noted that his 16 year-old patient had anemia; petechiae; microscopic hematuria; and at autopsy, disseminated microvascular thrombi. Since that time, the pathophysiology, etiology, and medical management of TTP has expanded.
References
- ↑ Moschcowitz E (1924). "An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries: an undescribed disease". Proc NY Pathol Soc. 24: 21–4. Reprinted in Mt Sinai J Med 2003;70(5):322-5, PMID 14631522.
- ↑ SCHULMAN I, PIERCE M, LUKENS A, CURRIMBHOY Z (1960). "Studies on thrombopoiesis. I. A factor in normal human plasma required for platelet production; chronic thrombocytopenia due to its deficiency". Blood. 16: 943–57. PMID 14443744.