Nephrotic syndrome risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mehrian Jafarizade, M.D [2]
Overview
Multiple risk factors may be involved in the nephrotic syndrome, such as family history, gender, and obesity. Also, diseases such as Hodgkin lymphoma, leukemia, viral diseases; and medications such as lithium, D-penicillamine can be risk factors for developing different types of nephrotic syndromes.
Risk factors
Risk factors of nephrotic syndrome depend on the type of syndromes, as below:
Common risk factors
Risk factors of development of minimal change disease include:[1]
- Children within the Age >1 year but <8 years
- Hodgkin lymphoma
- Leukemia
- Recent viral illness
- Toxins such as mercury, gold, bee stings, fire coral exposure.
- Medication such as[2]
- Salazopyrin
- Tiopronin
- Lithium
- D-penicillamine
- Tyrosine-kinase inhibitor
The following are considered risk factors for the development of focal segmental glomerulosclerosis (FSGS):[3]
- Male gender
- Black race
- Family history
- Heroin abuse
- Drugs known to be associated with FSGS
- Chronic viral infection
- Single kidney status
- Obesity
Less common risk factors
Below conditions and toxins can be a risk factor for nephrotic syndrome[4]
- Adaptation to nephron reduction
- Amyloidosis
- Bee sting
- Castleman's disease
- Chronic interstitial nephritis
- Dermatomyositis
- Diabetes mellitus
- Endocarditis
- Fabry's disease
- Food allergens
- Gold
- Goodpasture's syndrome
- Graft vs. host disease
- Henoch-Schonlein purpura
- Heroin
- HIV
- Infectious mononucleosis
- Interferon
- Kimura's disease
- Leukemia
- Lipoatrophy
- Lithium
- Lymphomas
- Malaria
- Mercury
- Mixed connective tissue disease
- Multiple myeloma
- NSAID
- Obesity
- Oligomeganephronia
- Orthostatic proteinuria
- Penicillamine
- Polyarteritis nodosa
- Pre-eclampsia
- Probenecid
- Renal vein thrombosis
- Rheumatoid arthritis
- Sarcoidosis
- Sickle cell anemia
- Sjogren's syndrome
- Sorafenib
- Streptococcal Infection
- Syphillis
- Systemic lupus erythematosus
- Thyroid disease
- Toxoplasmosis
- Vasculitis
- Viral hepatitis
Drug Induced
- Agalsidase beta
- Certolizumab pegol
- coagulation factor IX
- Olsalazine
- Sodium aurothiomalate
- Trimethadione
- Ziv-aflibercept
References
- ↑ Iijima, Kazumoto; Hamahira, Kiyoshi; Tanaka, Ryojiro; Kobayashi, Akiko; Nozu, Kandai; Nakamura, Hajime; Yoshikawa, Norishige (2002). "Risk factors for cyclosporine-induced tubulointerstitial lesions in children with minimal change nephrotic syndrome". Kidney International. 61 (5): 1801–1805. doi:10.1046/j.1523-1755.2002.00303.x. ISSN 0085-2538.
- ↑ Vivarelli M, Massella L, Ruggiero B, Emma F (February 2017). "Minimal Change Disease". Clin J Am Soc Nephrol. 12 (2): 332–345. doi:10.2215/CJN.05000516. PMC 5293332. PMID 27940460.
- ↑ Sohal, DS; Prabhakar, SS (November 02, 2011). "Focal segmental glomerulosclerosis" (PDF). Interchopen. InTech. Retrieved 3 December 2013. Check date values in:
|date=(help) - ↑ Eddy AA, Symons JM (2003). "Nephrotic syndrome in childhood". Lancet. 362 (9384): 629–39. doi:10.1016/S0140-6736(03)14184-0. PMID 12944064.