Toxic epidermal necrolysis medical therapy
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Toxic epidermal necrolysis Microchapters |
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Differentiating Toxic Epidermal Necrolysis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Medical Therapy
First line: early withdrawal of culprit drugs, early referral and management in burn units or intensive care units, supportive management, nutritional support
Second line: intravenous immunoglobulin (IVIG) - Uncontrolled trials showed promising effect of IVIG on treatment of TEN; a randomized control trial is needed in the future to determine the efficacy of IVIG in TEN.
Third line: cyclosporin, cyclophosphamide, plasmapheresis, pentoxifylline, N-acetylcysteine, ulinastatin, infliximab, granulocyte colony-stimulating factors (if TEN associated-leukopenia)
Systemic steroids are unlikely to offer any benefits.