Glucose-6-phosphate dehydrogenase deficiency historical perspective
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Glucose-6-phosphate dehydrogenase deficiency Microchapters |
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Differentiating Glucose-6-phosphate dehydrogenase deficiency from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]
Overview
Historical Perspective
Discovery
- [Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].[1]
- The association between primaquine and discovery of G6PD deficiency was made during a study at Illinois State Penitentiary. Prisoner volunteers were given primaquine and some of them developed hemolytic anemia.
- Numerous soldiers developed hemolytic anemia after taking primaquine to prevent relapsing infection by plasmodium vivax during Korean War.
- In spite of these results, the US military administered the drug widely during the Korean War to prevent the relapsing infection caused by Plasmodium vivax hypnozoites. Numerous cases of hemolytic anemia were observed in US soldiers of North African and Mediterranean descent.
- In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
- In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
Outbreaks
There have been several outbreaks of [disease name], which are summarized below:
Landmark Events in the Development of Treatment Strategies
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].
Impact on Cultural History
Famous Cases
The following are a few famous cases of disease name:
References
- ↑ Baird K (May 2015). "Origins and implications of neglect of G6PD deficiency and primaquine toxicity in Plasmodium vivax malaria". Pathog Glob Health. 109 (3): 93–106. doi:10.1179/2047773215Y.0000000016. PMC 4455359. PMID 25943156.