Von Willebrand disease historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Prince Tano Djan, BSc, MBChB [2]
Overview
- Von Willebrand's disease was first described by Erik Adolf von Willebrand, a Finnish paediatrician in 1926.[1][2]
- Dr. Erik Adolf von Willebrand was also the first to differeentiate Von Willebrand's disease from hemophilia.[2]
- Von Willebrand's disease was initially named hereditary pseudohemophilia.[2]
- In the mid 1950s it was recognized that Von Willebrand's disease was usually accompanied by the following:[3]
- A decreased level of coagulation factor VIII (FVIII) activity
- Bleeding phenotype could be corrected by the infusion of normal plasma.
- In the early 1970s the immunologic distinction between FVIII and von Willebrand factor was made.[3]
- In the 1980s, cloning of the VWF gene was investigated which has facilitated investigation into the genetic basis of VWD.[3][4][5][6][7]
Historical Perspective
- Von Willebrand's disease was first described by Erik Adolf von Willebrand, a Finnish paediatrician in 1926.[8][2]
- Dr. Erik Adolf von Willebrand was also the first to differeentiate Von Willebrand's disease from hemophilia.[2]
- Von Willebrand's disease was initially named hereditary pseudohemophilia.[2]
- In the mid 1950s it was recognized that Von Willebrand's disease was usually accompanied by the following:[3]
- A decreased level of coagulation factor VIII (FVIII) activity
- Bleeding phenotype could be corrected by the infusion of normal plasma.
- In the early 1970s the immunologic distinction between FVIII and von Willebrand factor was made.[3]
- In the 1980s, cloning of the VWF gene was investigated which has facilitated investigation into the genetic basis of VWD.[3][4][5][6][7]
References
- ↑ Template:WhoNamedIt
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Lenting PJ, Casari C, Christophe OD, Denis CV (2012). "von Willebrand factor: the old, the new and the unknown". J Thromb Haemost. 10 (12): 2428–37. doi:10.1111/jth.12008. PMID 23020315.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 James PD, Goodeve AC (2011). "von Willebrand disease". Genet Med. 13 (5): 365–76. doi:10.1097/GIM.0b013e3182035931. PMC 3832952. PMID 21289515.
- ↑ 4.0 4.1 Lynch DC, Zimmerman TS, Collins CJ, Brown M, Morin MJ, Ling EH; et al. (1985). "Molecular cloning of cDNA for human von Willebrand factor: authentication by a new method". Cell. 41 (1): 49–56. PMID 3873280.
- ↑ 5.0 5.1 Sadler JE, Shelton-Inloes BB, Sorace JM, Harlan JM, Titani K, Davie EW (1985). "Cloning and characterization of two cDNAs coding for human von Willebrand factor". Proc Natl Acad Sci U S A. 82 (19): 6394–8. PMC 390722. PMID 2864688.
- ↑ 6.0 6.1 Ginsburg D, Handin RI, Bonthron DT, Donlon TA, Bruns GA, Latt SA; et al. (1985). "Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization". Science. 228 (4706): 1401–6. PMID 3874428.
- ↑ 7.0 7.1 Verweij CL, Diergaarde PJ, Hart M, Pannekoek H (1986). "Full-length von Willebrand factor (vWF) cDNA encodes a highly repetitive protein considerably larger than the mature vWF subunit". EMBO J. 5 (8): 1839–47. PMC 1167049. PMID 3019665.
- ↑ Template:WhoNamedIt