Spondyloarthropathy epidemiology and demographics
epidemiology and demographics
Spondyloarthropathy (SpA) is a world wide disease but it has been seen mostly throughout Europe, Asia, North Africa, and North America, which are the places for presence of HLA-B27. SpA and HLA-B27 is somehow absent among genetically unmixed native populations of South Africa and Australia.
Here are some labeled data that shows not only the prevalence of spondyloarthropathies but also the prevalence of HLA-B27 and its subtype.
| Prevalence of AS and related spondyloarthropathies throughout different populations | |||||
|---|---|---|---|---|---|
| populations | B27 frequency | Prevalence of AS | Prevalence of SpA
(including AS) | ||
| General population | B27+ part of population | General population | B27+ part of population | ||
| Eskimos (Alaska) | 40% | 0.4% | .. | 2.5% | .. |
| Skimos (Alaska & Siberia) & Chukcki | 25-40% | .. | 1.6% | 2-3.4% | 4.2% |
| Samis (Lapland) | 24% | 1.8% | 6.8% | .. | .. |
| Northern Norway | 10-16% | 1.4% | .. | .. | .. |
| Mordovia | 16% | 0.5% | .. | .. | .. |
| Europe (Western) | 8% | 0.2% | 2% | .. | .. |
| Basic HLA-B27 subtypes and their geographical distribution | ||
|---|---|---|
| HLA-B27 subtype | Geographical appearance | Assocoation |
| HLA-B*2702 | Mediterranean populations | Association with AS |
| HLA-B*2704 | Major subtype in Chinese and Japanese populations | Association with SpA |
| HLA-B*2705 | Major subtype in Caucasians | Strong association with AS |
| HLA-B*2706 | Healthy populations in Southeast Asia | Very weak association with SpA |
| HLA-B*2709 | Healthy population of Sardinia | AS sparing |
..