Spondyloarthropathy risk factors

Spondyloarthropathy risk factors

Since the role of genetic in the presence of spondyloarthropathies have been known since several years ago, genetically predisposing individuals are who have HLA-B27 gene, are at risk of developing spondyloarthropathies.

The risk of developing spondyloarthropathies in individuals with HLA-B27 gene is 1-2%, however, it can increase to 15-20% if he/she have a first-degree relative with positive HLA-B27 gene and developed spondyloarthropathy.

There some genes that are suspicious for their association in SpA, which are included:

• HLA-B27
  • HLA-B*2702 (Association with AS)
  • HLA-B*2704 (Association with SpA)
  • HLA-B*2705 (Strong association with AS)
  • HLA-B*2706 (Very weak association with SpA)
  • HLA-B*2709 (AS sparing)
• ERAP1
• IL23R
• TNFRSF1A
• TRADD
• TNFSF15
• IL1A
• IL1R2
• CARD9
• ANTXR2