Splenomegaly

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Definitions

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Symptoms of Splenomegaly

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Treatment of Splenomegaly

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List of terms related to Splenomegaly

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Gichoya Judy Wawira [2], Moi University School of Medicine

Synonyms and keywords: Spleen enlargement; enlarged spleen; spleen swelling

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Splenomegaly from Other Diseases

Category Disease Etiology Clinical manifestations Para−clinical findings Gold standard Associated findings
Demography History Symptoms Signs Lab Findings Imaging
Fever Fatigue Weight loss Abdominal pain Bleeding BP JVP Jaundice Ascites Other CBC PS Iron LFT PT/PTT BUN/Cr UA
WBC Hb Plt
Congestive Cirrhosis Any - + + + + +
Heart failure
Thrombosis of portal, hepatic, or splenic veins
Malignancy Lymphoma
Leukemia
Polycythemia Vera
Multiple myeloma
Essential thrombocythemia
Primary myelofibrosis
Primary splenic tumors
Metastatic solid tumors
Category Disease Etiology Demography History Fever Fatigue Weight loss Abdominal pain Bleeding BP JVP Jaundice Ascites Other WBC Hb Plt PS Iron LFT PT/PTT BUN/Cr UA Imaging Gold standard Associated findings
Infection Viral Hepatitis
Infectious mononucleosis
Cytomegalovirus
Bacterial Salmonella
Brucella
Tuberculosis
Parasitic Malaria
Schistosomiasis
Toxoplasmosis
Kala-azar Visceral leishmaniasis
Infective endocarditis
Fungal
Inflammation Sarcoidosis
Serum sickness
Systemic lupus erythematosus
Felty syndrome
Category Disease Etiology Demography History Fever Fatigue Weight loss Abdominal pain Bleeding BP JVP Jaundice Ascites Other WBC Hb Plt PS Iron LFT PT/PTT BUN/Cr UA Imaging Gold standard Associated findings
Infiltrative Gaucher disease
Niemann-Pick disease
Amyloidosis
Langerhans cell histiocytosis
Hemophagocytic lymphohistiocytosis
Rosai-Dorfman disease
Hematologic (hypersplenic) states Hemolytic anemia
Sickle cell disease
Granulocyte colony-stimulating factor
Category Disease Etiology Demography History Fever Fatigue Weight loss Abdominal pain Bleeding BP JVP Jaundice Ascites Other WBC Hb Plt PS Iron LFT PT/PTT BUN/Cr UA Imaging Gold standard Associated findings

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Treatment

Case Studies

Case #1

Related Chapters

References