Waldenström's macroglobulinemia history and symptoms
|
Waldenström's macroglobulinemia Microchapters |
|
Differentiating Waldenström's macroglobulinemia from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Waldenström's macroglobulinemia history and symptoms On the Web |
|
American Roentgen Ray Society Images of Waldenström's macroglobulinemia history and symptoms |
|
Waldenström's macroglobulinemia history and symptoms in the news |
|
Blogs on Waldenström's macroglobulinemia history and symptoms |
|
Directions to Hospitals Treating Waldenström's macroglobulinemia |
|
Risk calculators and risk factors for Waldenström's macroglobulinemia history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
Overview
Many patients with Waldenström macroglobulinemia are asymptomatic. The disease is subtle and nonspecific. The most common symptoms of Waldenström macroglobulinemia include weakness, anorexia, blurry vision,peripheral neuropathy, and weight loss. Less common symptoms of the disease include bleeding and Raynaud phenomenon.
History and Symptoms
History
- The onset of Waldenström macroglobulinemia is insidious and nonspecific.
- Approximately 25% of patients with WM are asymptomatic upon presenation; their diagnosis is often made incidentally from routine blood tests.[1]
Common Symptoms
Common symptoms of Waldenström macroglobulinemia include:
- Constitutional B symptoms
- Weakness
- Anorexia
- Weight loss
- Fever
- Peripheral neuropathy
- Blurry vision
Less Common Symptoms
Less common symptoms of Waldenström macroglobulinemia include:
- Raynaud phenomenon
- Due to cryoglobulinemia
- Bleeding
- Mental status changes
- Due to infiltration of central nervous system
- Causes Bing-Neel syndrome which includes confusion, memory loss, and motor abnormalities
- Diarrhea/steatorrhea
- Due to deposition of IgM protein in the lamina propria of the intestinal wall
Symptoms Secondary to Hyperviscosity
Hyperviscosity syndrome occurs due to the accumulation of monoclonal IgM proteins in the blood.
Clinical manifestations of hyperviscosity syndrome occur only if serum viscosity is >4 centipoises and include:
- Retinal hemorrhage with blurring of vision
- Vertigo
- Dizziness
- Headache
- Nystagmus
- Tinnitus
- Ataxia
- Bleeding
References
- ↑ García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A; et al. (2001). "Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases". Br J Haematol. 115 (3): 575–82. PMID 11736938.