Myelofibrosis differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2], Sujit Routray, M.D. [3]
Overview
Myelofibrosis must be differentiated from other diseases that cause diffuse bone sclerosis, splenomegaly, anemia, leukopenia, thrombocytopenia, leukocytosis, thrombocytosis, and extramedullary hematopoiesis such as sickle cell disease, hyperthyroidism, sclerosing bone dysplasia, osteoblastic metastases, Paget's disease, acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), polycythemia vera, myelodysplastic syndromes, chronic myelomonocytic leukemia, cirrhosis, infections neoplastic and lipid storage disorders.[1][2] Myelofibrosis must be differentiated from other diseases that cause splenomegaly, such as anemia, CML, polycythemia rubra vera, cirrhosis, infections, neoplastic, and lipid storage disorders.[1][3]
Differentiating Myelofibrosis from other Diseases
Myelofibrosis must be differentiated from other diseases that cause diffuse bone sclerosis. They are presented in the table below.[1][2]
| Type of diseases | Diseases |
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| Hematological causes | Sickle cell disease |
| Metabolic bone disorders | Hyperthyroidism Hypoparathyroidism Renal osteodystrophy |
| Congenital | Sclerosing bone dysplasia Osteopetrosis Pyknodysostosis |
| Malignancy | Lymphoma: infiltration Leukaemia: infiltration Osteoblastic metastases |
| Other | Paget disease Fluorosis Mastocytosis Hepatitis C associated osteosclerosis (HCAO) |
Myelofibrosis must be differentiated from other diseases that cause splenomegaly. They are presented in the table below.[1][3]
References
- ↑ 1.0 1.1 1.2 1.3 Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016
- ↑ 2.0 2.1 Diffuse bony sclerosis: differential diagnosis. Dr Craig Hacking and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/diffuse-bony-sclerosis-differential-diagnosis. Accessed on March 10, 2016
- ↑ 3.0 3.1 Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/Italic textarticles/splenomegaly. Accessed on March 11, 2016