Myelofibrosis risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Myelofibrosis is a rare disorder and its common risk factors may be age, other myeloproliferative disorders, radiation, or industrial chemical exposure.
Risk Factors
Common risk factors in the development of myelofibrosis include:
- Age: Old age seem to be an important risk factor with individuals being in their 50s and 60s.[1]
- Other myeloproliferative disorder: Other myeloproliferative disorders such as polycythemia vera and essential thrombocythemia, may pave the way for the development of myelofibrosis.[2][3][4]
- Radiation exposure: Individuals exposed to high levels of radiation (e.g. Thorotrast) have an increased risk of myelofibrosis.
- Chemicals: Industrial chemicals, such as toluene and benzene, may have an increased risk of developing myelofibrosis.
References
- ↑ Kreft A, Wiese B, Weiss M, Choritz H, Buhr T, Büsche G, Georgii A (March 2004). "Analysis of risk factors of the evolution of myelofibrosis in pre-fibrotic chronic idiopathic myelofibrosis: a retrospective study based on follow up biopsies of 70 patients by using the RECPAM method". Leuk. Lymphoma. 45 (3): 553–9. PMID 15160918.
- ↑ Boiocchi L, Mathew S, Gianelli U, Iurlo A, Radice T, Barouk-Fox S, Knowles DM, Orazi A (December 2013). "Morphologic and cytogenetic differences between post-polycythemic myelofibrosis and primary myelofibrosis in fibrotic stage". Mod. Pathol. 26 (12): 1577–85. doi:10.1038/modpathol.2013.109. PMID 23787440.
- ↑ Passamonti F, Giorgino T, Mora B, Guglielmelli P, Rumi E, Maffioli M, Rambaldi A, Caramella M, Komrokji R, Gotlib J, Kiladjian JJ, Cervantes F, Devos T, Palandri F, De Stefano V, Ruggeri M, Silver RT, Benevolo G, Albano F, Caramazza D, Merli M, Pietra D, Casalone R, Rotunno G, Barbui T, Cazzola M, Vannucchi AM (December 2017). "A clinical-molecular prognostic model to predict survival in patients with post polycythemia vera and post essential thrombocythemia myelofibrosis". Leukemia. 31 (12): 2726–2731. doi:10.1038/leu.2017.169. PMID 28561069.
- ↑ Masarova L, Bose P, Daver N, Pemmaraju N, Newberry KJ, Manshouri T, Cortes J, Kantarjian HM, Verstovsek S (August 2017). "Patients with post-essential thrombocythemia and post-polycythemia vera differ from patients with primary myelofibrosis". Leuk. Res. 59: 110–116. doi:10.1016/j.leukres.2017.06.001. PMC 5573611. PMID 28601551.