Lymphomatoid granulomatosis differential diagnosis
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Differentiating Lymphomatoid granulomatosis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Lymphamtoid granulomatosis must be differentiated from Bronchocentric granulomatosis and Churg-Strauss, Necrotizing sarcoid granulomatosis, Wegeners granulomatosis, Hodgkins disease, Non-hodgkin lymphoma, and Nasal angiocentric lymphoma
Differentiating Lymphamatoid granulomatosis from other Diseases
As Lymphamatoid granulomatosis manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtypes pulmonary being the most common. The sub types are the following:
- Pulmonary
- CNS
- Dermatologic
Pulmonary Lymphamatoid granulomatosis must be differentiated from other diseases that cause:
- Cough(non-productive, rarely hemoptysis can occur)
- Dyspnea
- Chest tightness
Other Symptoms that are asscociated with the pulmonary symptoms are:
- Malaise
- Weight loss
- Fatigue
From the symptoms listed above; Lymphamatoid granulomatosis is usually differtiated from the following diseases Bronchocentric granulomatosis and Churg-Strauss, Necrotizing sarcoid granulomatosis, Wegeners granulomatosis, Hodgkins disease, Non-hodgkin lymphoma, and Nasal angiocentric lymphoma.
In contrast, CNS lymphamatoid granulomatosis must be differentiated from other diseases that cause:
- mental status changes
- Headaches
- Seizures
- Hemiparesis
- Ataxia
The differentials are the following CVA and Brain tumors or CNS lymphoma.
Finally Dermatologic Lymphamatoid granulomatosis must also be differtiated from other diseases that cause:
- Erythematous rash
- Macules
- Papules
- Plaques
- Subcutaneous nodules
- Larger ulcerated nodules
The differentials are the following dermatomyositis, and Psoriasis
Differentiating Lymphamatoid Granulomatosis
On the basis of Cough, Dyspnea, and Chest tightness, Lymphamatoid granulomatosis must be differentiated from Bronchocentric granulomatosis and Churg-Strauss, Necrotizing sarcoid granulomatosis, Wegeners granulomatosis, Hodgkins disease, Non-hodgkin lymphoma, and Nasal angiocentric lymphoma.
| Diseases | Clinical manifestations | Para-clinical findings | Gold standard | Additional findings | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symptoms | Physical examination | ||||||||||||||
| Lab Findings | Imaging | Histopathology | |||||||||||||
| Cough | Dyspnea | Chest tightness | Auscultation | Physical exam 2 | Physical exam 3 | Lab 1 | Lab 2 | Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | ||||
| Bronchocentric granulomatosis | |||||||||||||||
| Churg-Strauss syndrome | |||||||||||||||
| Necrotizing sarcoid granulomatosis | |||||||||||||||
| Diseases | Symptom 1 | Symptom 2 | Symptom 3 | Physical exam 1 | Physical exam 2 | Physical exam 3 | Lab 1 | Lab 2 | Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | Histopathology | Gold standard | Additional findings |
| Wegeners granulomatosis | |||||||||||||||
| Hodgkin disease | |||||||||||||||
| Non-hodgkin lymphoma | |||||||||||||||