Multiple myeloma causes

Multiple myeloma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]

Overview

The causes of multiple myeloma include sporadic mutations, such as TP53 mutation, and inherited predisposition.

Causes

Common causes

The causes of multiple myeloma include:

• Sporadic mutations and genetic predisposition
• Mutations in tumor suppressors or oncogenes
• Mutations in the tumor suppressor TP53 (most common)
• Chromosomal aberrations such as translocations can trigger the onset of malignancy and allow for uncontrolled plasma cell proliferation.

Less common causes

• Familial causes are less contributory to the development of multiple myeloma compared to sporadic causes.