Glanzmann's thrombasthenia secondary prevention

	Glanzmann's thrombasthenia
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2], Niyousha Danesh, MD-MPH

Overview

DDAVP prevents bleeding after dental extraction and minor surgery in patients with milder platelet defects. Glanzmann's thrombasthenia patients need regular dental visits and must maintain good oral hygiene because the recurrence of gingival bleeding is more in them. These patient should avoid contact sports. Estrogens, platelet transfusion, antifibrinolytic agents, and recombinant human factor VIIa are some other therapies used for treatment/prevention.

DDAVP prevents bleeding after dental extraction and minor surgery in patients with milder platelet defects^[1]^[2]. Glanzmann's thrombasthenia patients need regular dental visits and must maintain good oral hygiene because the recurrence of gingival bleeding is more in them. These patient should avoid contact sports. Estrogens, platelet transfusion, antifibrinolytic agents, and recombinant human factor VIIa are some other therapies used for treatment/prevention.

↑ Piot B, Sigaud-Fiks M, Huet P, Fressinaud E, Trossaërt M, Mercier J (March 2002). "Management of dental extractions in patients with bleeding disorders". Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 93 (3): 247–50. PMID 11925531.
↑ Kosch A, Kehrel B, Nowak-Göttl U, Häberle J, Jürgens H (1999). "[Thrombocytic alpha-delta-storage-pool-disease: shortening of bleeding time after infusion of 1-desamino-8-D-arginine vasopressin]". Klin Padiatr (in German). 211 (4): 198–200. doi:10.1055/s-2008-1043787. PMID 10472549.