Breast lumps natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

If benign breast lumps left untreated, those proved to be benign both by clinical examination and cytological diagnosis, do not become malignant and 68% of benign breast lumps resolve by time mostly after 2 years .

Benign breast lumps should approved to be benign both clinically and cytologicaly. Because some of breast lumps which thought to be benign ones can turn to be malignant by cytological results

breast lumps which approved to be benign both clinically and cytologicaly in women under 35 years can resolve over time if do not excised

Natural History, Complications, and Prognosis

Natural History

• Natural history of breast lumps did not well-studied and little is known about it
• Regarding to prevent missed malignancy and patient's reassurance, benign breast lumps are excised
• The symptoms of benign breast lumps,especially fibroadenomas, usually develop in the second and third decade of life, and discrete breast lumps considered to be benign by clinical examination
• If left untreated, 68% of patients with benign breast lumps may regress over 2 years
• The histological reason for resolution of breast lumps is associated with the fact that lumps merge into stroma and hyalinization

Complications

• Common complications of breast lumps include
  • May develop into malignant lesion
    • Assessment of malignancy risk in fibroadenomas is low
    • No adenocarcinoma reported in fibroadenoma, only lobular neoplasia was seen in fibroaadenomas

Prognosis

• Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
• Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
• The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
• [Subtype of disease/malignancy] is associated with the most favorable prognosis.
• The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.