Myelofibrosis MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]

Overview

MRI may be helpful in the diagnosis of myelofibrosis. Findings on MRI suggestive of myelofibrosis include diffuse decrease in bone marrow signal intensity.

MRI may be helpful in the diagnosis of myelofibrosis and can be useful in evaluating the stage and the progression of disease.
Findings on MRI suggestive of myelofibrosis include:

Diffuse decrease in bone marrow signal intensity.^[1]^[2]^[3]
Very low, mainly homogeneous signal on both T1- and T2-weighted images^[4]
Foci of extramedullary hematopoiesis (EMH) involving the spine manifest as heterogeneous and predominantly hyperintense masses
Foci of intracranial extramedullary hematopoiesis (EMH) manifest as masses of variable signal intensity^[5]

_{MR images demonstrate diffuse decrease bone marrow signal intensity in this patient with myelofibrosis.^[6]}

↑ Radiographic features of myelofibrosis. Radswiki. Radiopaedia 2016. http://radiopaedia.org/cases/myelofibrosis-1. Accessed on March 14, 2016
↑ Ueda F, Takashima T, Suzuki M, Kadoya M (1994). "MR diagnosis of myelofibrosis". Radiat Med. 12 (3): 135–7. PMID 7972898.
↑ Lanir A, Aghai E, Simon JS, Lee RG, Clouse ME (1986). "MR imaging in myelofibrosis". J Comput Assist Tomogr. 10 (4): 634–6. PMID 3734203.
↑ Guermazi A, de Kerviler E, Cazals-Hatem D, Zagdanski AM, Frija J (1999). "Imaging findings in patients with myelofibrosis". Eur Radiol. 9 (7): 1366–75. doi:10.1007/s003300050850. PMID 10460376.
↑ Koch BL, Bisset GS, Bisset RR, Zimmer MB (June 1994). "Intracranial extramedullary hematopoiesis: MR findings with pathologic correlation". AJR Am J Roentgenol. 162 (6): 1419–20. doi:10.2214/ajr.162.6.8192010. PMID 8192010.
↑ Image courtesy of Radswiki. Radiopaedia (original file here). Creative Commons BY-SA-NC